Condition

Non Muscle Invasive Bladder Cancer clinical trials and research

• 31Clinical trials
• 23Countries

Newest Non Muscle Invasive Bladder Cancer clinical trials

All recruiting trials (31)

• NMIBC sample collection to test cancer monitoring biomarkers

  This study tests a blood, urine, and tumor tissue collection approach in people with high-risk non-muscle invasive bladder cancer to see if a molecular test can detect residual disease and monitor recurrence.

  Recruiting Natera, Inc. · Austin, Texas · NCT07763197

• Sequential Gemcitabine Plus Docetaxel vs Gemcitabine Plus Mitomycin C for BCG-Unresponsive NMIBC

  This study tests whether adding docetaxel after gemcitabine is better or worse than adding mitomycin C after gemcitabine for people with BCG-unresponsive high-grade non-muscle-invasive bladder cancer.

  Recruiting Phase 2 Blokhin's Russian Cancer Research Center · Moscow, Moscow · NCT07747740

• Is ongoing systemic immunotherapy needed after achieving tumor-free status in very-high-risk NMIBC?

  This study tests whether patients who have become tumor-free after a systemic immunotherapy-based bladder-sparing treatment can safely stop therapy and instead be watched closely.

  Recruiting at 4 sites Phase 2 Tianjin Medical University Second Hospital · Tianjin and 3 other locations · NCT07625527

• Comparing CT and MRI with VI-RADS for Bladder Cancer Staging

  This study tests how well CT and MRI with VI-RADS can correctly stage bladder cancer before surgery in adults.

  Recruiting Oslo University Hospital · Oslo · NCT07602010

• How bladder microbes and immune signals affect lower urinary tract health

  This project will test whether differences in bladder microbes and immune signals are linked to urinary tract health in adults with and without various urinary conditions.

  Recruiting University of Zurich · Zurich, Canton of Zurich · NCT07494864

• Cretostimogene for BCG‑unresponsive high‑grade non‑muscle‑invasive bladder cancer

  This treatment will test cretostimogene plus n‑dodecyl‑β‑D‑maltoside in adults whose high‑grade non‑muscle‑invasive bladder cancer did not respond to BCG (carcinoma in situ with or without Ta/T1 tumors).

  Recruiting at 14 sites Phase 2 Lepu Biopharma Co., Ltd. · Beijing, Beijing Municipality and 13 other locations · NCT07283835

• Testing PF-08052667 for high-risk non-muscle invasive bladder cancer

  This study will test whether the new medicine PF-08052667, alone or with BCG and/or sasanlimab, helps adults with high-risk non-muscle invasive bladder cancer that has come back or not responded to standard treatment.

  Recruiting at 66 sites Phase 1 Pfizer · Birmingham, Alabama and 68 other locations · NCT07206225

• AI-enhanced blue light cystoscopy for bladder cancer detection

  This project will collect blue light cystoscopy videos from adults having Hexvix/Cysview-enhanced cystoscopy and test AI tools to help doctors better find bladder cancer during the procedure.

  Recruiting at 12 sites Photocure · Tampa, Florida and 11 other locations · NCT07144319

• Need for a second transurethral resection in high-risk NMIBC patients with negative urine genome-wide low-depth sequencing after initial resection

  This trial will test whether people with high-risk non-muscle-invasive bladder cancer who have a negative urine genome-wide low-depth sequencing result can safely skip a planned second transurethral resection.

  Recruiting The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT07036731

• Radiotherapy for BCG-Unresponsive Bladder CIS

  This study tests whether radiation therapy can help people with BCG-unresponsive non-muscle-invasive bladder cancer to delay or avoid bladder removal.

  Recruiting at 3 sites European Organisation for Research and Treatment of Cancer - EORTC · Anderlecht, Brussels Capital and 2 other locations · NCT06990061

• Intravesical chemotherapy with systemic pembrolizumab for high-risk non-muscle invasive bladder cancer that did not respond to or was exposed to BCG

  This study tests whether giving intravesical chemotherapy together with pembrolizumab can help people with high-risk non-muscle invasive bladder cancer who didn’t fully respond to BCG therapy.

  Recruiting Phase 2 Blatam · Caba · NCT06972615

• Comparing treatments for non-muscle invasive bladder cancer

  This study is testing a new treatment called nadofaragene firadenovec against standard options for adults with non-muscle invasive bladder cancer who haven’t had success with previous treatments.

  Recruiting at 7 sites Phase 3 Memorial Sloan Kettering Cancer Center · Baltimore, Maryland and 8 other locations · NCT06929286

• Chemoablation versus bladder resection with adjuvant chemotherapy for recurrent Ta low-grade bladder tumors

  This study will test whether a dose-dense Mitomycin C chemoablation approach (with adjuvant BCG for non-responders) works better than standard TURBT plus intravesical therapy for adults with small recurrent Ta low-grade bladder tumors.

  Recruiting at 3 sites Phase 4 Aarhus University Hospital · Aalborg and 7 other locations · NCT06781879

• Evaluating a new treatment for high-grade non-muscle invasive bladder cancer

  This study is testing a new bladder cancer treatment that delivers medication directly into the bladder to see if it can better kill cancer cells and lower the chances of the cancer coming back for people with high-grade non-muscle invasive bladder cancer.

  Recruiting Phase 2 Relmada Therapeutics, Inc. · Raanana · NCT06663137

• Combining Durvalumab and Monalizumab for Bladder Cancer Treatment

  This study is testing a combination of two drugs, durvalumab and monalizumab, to see if they can help people with certain types of bladder cancer that haven't responded to standard treatment.

  Recruiting at 5 sites Phase 2 Hoosier Cancer Research Network · San Francisco, California and 4 other locations · NCT06503614

• Evaluating the need for repeat bladder surgery in patients with negative urine biomarker tests

  This study is testing if patients with non-muscle-invasive bladder cancer who have negative urine biomarker tests can skip repeat bladder surgery and still do well.

  Recruiting The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT06287541

• Evaluating Hydeal Cyst® for Bladder Cancer Treatment

  This study is testing if a new treatment called Hydeal Cyst® can help people with non-muscle invasive bladder cancer who are already getting chemotherapy or immunotherapy.

  Recruiting at 8 sites Istituto Oncologico Veneto IRCCS · Bergamo and 8 other locations · NCT06245603

• Tracking quality of life and relapses in bladder cancer patients after surgery

  This study is tracking how bladder cancer patients feel and whether their cancer comes back after surgery over the next 10 years.

  Recruiting IRCCS San Raffaele · Milan, MI · NCT06167356

• MRI (VI-RADS) plus photodynamic-guided TURBT to avoid routine repeat bladder resections

  This study tests whether using a preoperative MRI VI-RADS score together with photodynamic-assisted TURBT can let people with non-muscle-invasive bladder cancer safely skip a routine second resection.

  Recruiting Phase 4 University of Roma La Sapienza · Rome, Lazio · NCT05962541

• Investigating TARA-002 for treating high-grade bladder cancer

  This study is testing a new treatment called TARA-002 to see if it can help adults with high-grade bladder cancer feel better and fight the disease.

  Recruiting at 67 sites Phase 2 Protara Therapeutics · Homewood, Alabama and 77 other locations · NCT05951179

• AI tool to predict treatment response in bladder cancer

  This study is testing a new AI tool that helps doctors predict how well bladder cancer patients will respond to certain treatments, so they can make better choices for those at risk of their cancer coming back.

  Recruiting at 2 sites University of Texas Southwestern Medical Center · Dallas, Texas and 1 other locations · NCT05825950

• Replacing invasive bladder cancer monitoring with urine tests

  This study is testing if urine tests can replace some bladder cancer check-ups that usually require invasive procedures, to see if they can still keep patients safe while making their experience easier.

  Recruiting at 8 sites Phase 2 White River Junction Veterans Affairs Medical Center · West Haven, Connecticut and 9 other locations · NCT05796375

• Mindfulness and exercise program for bladder cancer surgery patients

  This study is testing a home program that combines exercise and mindfulness to help bladder cancer patients feel better and prepare for their surgery.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT05790850

• Treatment for recurrent bladder cancer using STM-416

  This study is testing a new treatment called STM-416 for people with recurrent bladder cancer to see if it's safe and how well it works compared to standard care.

  Recruiting at 19 sites Phase 1/2 SURGE Therapeutics · Mesa, Arizona and 19 other locations · NCT05710848

• Evaluating mood changes in bladder cancer patients treated with BCG

  This study is trying to see how BCG treatment for bladder cancer affects the mood of patients by tracking their anxiety and depression levels during the therapy.

  Recruiting Johns Hopkins University · Washington D.C., District of Columbia · NCT05672615

• New treatment for non-muscle-invasive bladder cancer using targeted chemotherapy

  This study is testing a new way to deliver chemotherapy directly into the bladder to see if it helps people with non-muscle-invasive bladder cancer that hasn't responded to standard treatment.

  Recruiting Phase 1 VA Office of Research and Development · Boston, Massachusetts · NCT05519241

• Outpatient laser treatment for recurrent bladder cancer

  This study is testing if a new outpatient laser treatment can safely help people with recurring low-grade bladder cancer without the need for general anesthesia.

  Recruiting Aarhus University Hospital · Aarhus · NCT05337397

• Using bicalutamide with BCG treatment for bladder cancer

  This study is testing if adding a drug called bicalutamide to the standard BCG treatment can help people with non-muscle invasive bladder cancer have fewer recurrences of their cancer.

  Recruiting at 7 sites Phase 2 CHU de Quebec-Universite Laval · London, Ontario and 6 other locations · NCT05327647

• Testing a new drug for bladder cancer that didn't respond to standard treatment

  This study is testing a new drug called 2141-V11 in people with bladder cancer who haven't responded to regular treatments to see if it can help them.

  Recruiting at 7 sites Phase 1/2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT05126472

• Registry for managing and following up on non-muscle-invasive bladder cancer

  This study is trying to see how well current treatments and urine tests work for people with non-muscle-invasive bladder cancer to help doctors manage their care better.

  Recruiting at 44 sites Association Francaise d'Urologie · Aix-en-Provence and 43 other locations · NCT05002556

• EG-70 treatment for patients with high-risk non-muscle invasive bladder cancer

  This study is testing a new gene therapy called EG-70 to see if it can help patients with high-risk bladder cancer who haven't responded to or haven't received standard treatment.

  Recruiting at 100 sites Phase 1/2 enGene, Inc. · Birmingham, Alabama and 101 other locations · NCT04752722

Related topics

Quick answers

How many Non Muscle Invasive Bladder Cancer clinical trials are recruiting right now?

31, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 23 countries. The most sites are in United States (14 trials), Canada (4 trials), Italy (4 trials), China (4 trials), France (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 9, Phase 1/2: 3, Phase 1: 2, Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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