Evaluating the need for repeat bladder surgery in patients with negative urine biomarker tests

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates whether patients with non-muscle-invasive bladder cancer (NMIBC) who test negative for urine biomarkers can safely avoid a repeat transurethral resection of bladder tumor (reTURBT). Participants who have undergone an initial TURBT will be randomized into two groups: one group will not receive reTURBT, while the other will undergo the procedure. The study aims to compare recurrence-free survival rates between the two groups to determine if the urine biomarker test can effectively guide treatment decisions. The trial adheres to ethical guidelines and maintains participant confidentiality throughout the study.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with NMIBC who have undergone initial TURBT and are scheduled for reTURBT surgery as recommended by guidelines or chosen by their physicians;
* Patients who have tested negative for urine biomarkers after the initial TURBT and before the second TURBT;
* Age ≥ 18 years;
* Willingness to provide personal basic clinical information, as well as pathology and subsequent recurrence monitoring results;
* Willingness to sign informed consent.

Exclusion Criteria:

* Patients with other non-urothelial malignant tumors (including prostate cancer and renal cell carcinoma);
* Patients previously diagnosed with muscle-invasive bladder cancer;
* Patients unable to undergo a second transurethral resection;
* Patients with incomplete sample pathology information;
* Any condition perceived by the researcher to potentially harm the subjects or prevent them from meeting or executing the study requirements;
* Patients unable to provide written informed consent.

Where it's running

• The First Affiliated Hospital of Nanjing Medical University
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Qiang Lv, Ph.D
• Email: doctorlvqiang@sina.com

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.