Condition

Muscle Invasive Bladder Cancer (MIBC) clinical trials and research

• 8Clinical trials
• 8Countries

Newest Muscle Invasive Bladder Cancer (MIBC) clinical trials

All recruiting trials (8)

• Perioperative systemic therapies in muscle-invasive bladder cancer (GUARDIANS)

  This registry will see how real-world perioperative treatments for muscle-invasive bladder cancer work in adults, including regimens like Enfortumab Vedotin with Pembrolizumab and cisplatin-based plans.

  Recruiting LMU Klinikum · Munich · NCT07855926

• Blood test for detecting tumor DNA in bladder and upper tract cancer

  A blood test that looks for tumor DNA in people with muscle-invasive bladder cancer or upper tract urothelial cancer is being tested to see if it matches what’s found in tumor tissue and if it can help track recurrence or remission over two years.

  Recruiting AZ Sint-Lucas Gent · Ghent, East Flanders · NCT07756437

• Enfortumab Vedotin plus Toripalimab vs Gemcitabine-Cisplatin as Neoadjuvant Therapy for Locally Advanced or High-Risk Muscle-Invasive Bladder Cancer

  This study tests if Enfortumab Vedotin with Toripalimab before surgery helps patients with locally advanced or high-risk muscle-invasive bladder cancer, compared with the standard Gemcitabine plus Cisplatin.

  Recruiting Phase 2 Peking University Third Hospital · Beijing, Beijing Municipality · NCT07647289

• Comparing CT and MRI with VI-RADS for Bladder Cancer Staging

  This study tests how well CT and MRI with VI-RADS can correctly stage bladder cancer before surgery in adults.

  Recruiting Oslo University Hospital · Oslo · NCT07602010

• Neoadjuvant zanidatamab and tislelizumab with chemotherapy to try to preserve the bladder in HER2-positive muscle-invasive bladder cancer

  This study tests whether giving zanidatamab and tislelizumab with chemotherapy before surgery can allow people with HER2-positive muscle-invasive bladder cancer to keep their bladder.

  Recruiting at 12 sites Phase 2 Fujian Medical University Union Hospital · Fuzhou, Fujian and 11 other locations · NCT07296705

• Home IV fluid infusions after radical cystectomy

  This trial will test whether giving home IV fluids after radical cystectomy for bladder cancer reduces 90-day hospital readmissions.

  Recruiting Johns Hopkins University · Baltimore, Maryland and 1 other locations · NCT07225205

• MRI-first treatment pathway for muscle-invasive bladder cancer

  This trial tests whether using a multiparametric bladder MRI to skip a staging TURBt can speed up care for people with biopsy-proven muscle-invasive bladder cancer.

  Recruiting Phase 3 University of Rome Tor Vergata · Rome, RM · NCT07067749

• Assessing safety and efficacy of new treatments for advanced solid tumors

  This study is testing two new treatments for patients with advanced solid tumors to see if they are safe and effective.

  Recruiting at 10 sites Phase 1/2 Lumara Bio Oncologics GmbH · Melbourne and 9 other locations · NCT05706129

Related topics

Quick answers

How many Muscle Invasive Bladder Cancer (MIBC) clinical trials are recruiting right now?

8, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in China (2 trials), Germany (1 trial), United States (1 trial), Italy (1 trial), Australia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 3: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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