Condition

Muscle-Invasive Bladder Carcinoma clinical trials and research

• 18Clinical trials
• 1New in 30 days
• 7Countries

Newest Muscle-Invasive Bladder Carcinoma clinical trials

All recruiting trials (18)

• Bladder cancer: test a biomarker-guided plan after neoadjuvant therapy

  This phase 2 study tests a biomarker- and response-guided plan to preserve the bladder in patients with muscle-invasive bladder cancer after neoadjuvant therapy.

  Recruiting Phase 2 Fox Chase Cancer Center · Philadelphia, Pennsylvania · NCT07908979

• Consolidative therapy after initial response in advanced bladder cancer

  This pilot trial tests adding radiation or surgery after a good response to EV + pembrolizumab in unresectable or oligometastatic muscle-invasive bladder cancer to see if residual disease can be eliminated or delayed from growing.

  Recruiting Phase 1/2 University of Washington · Seattle, Washington · NCT07579195

• Sexual health support after bladder cancer treatment

  This project will try sexological support to help adults about 12 months after bladder cancer treatment improve sexual function and intimacy.

  Recruiting University of Aarhus · Aarhus · NCT07339761

• Ureteral stent versus no stent for adults having radical cystectomy with an ileal conduit

  This trial tests whether placing temporary ureteral stents at the time of radical cystectomy with ileal conduit reduces post-operative complications compared with not placing stents in adults having cystectomy for bladder or other pelvic cancers.

  Recruiting Thomas Jefferson University · Philadelphia, Pennsylvania and 1 other locations · NCT07234968

• Assessing late images in PET-CT for bladder cancer staging

  This study is testing if taking later images during a PET-CT scan can help better identify lymph node involvement in patients with muscle-invasive bladder cancer.

  Recruiting Hopital Foch · Suresnes, Île-de-France Region · NCT06537960

• Neoadjuvant chemotherapy followed by watchful waiting versus immediate bladder treatment for muscle-invasive bladder cancer

  This trial will test whether people whose cancer appears to be gone after chemotherapy can safely skip immediate bladder removal or chemo-radiation and be followed with active surveillance instead.

  Recruiting Phase 2/3 University of British Columbia · Vancouver, British Columbia · NCT06537154

• Personalized cancer vaccine for patients with muscle-invasive bladder cancer

  This study is testing a personalized cancer vaccine to see if it can help patients with muscle-invasive bladder cancer fight their disease by boosting their immune response.

  Recruiting Phase 1 Washington University School of Medicine · Orlando, Florida and 2 other locations · NCT06529822

• Treatment for solid tumors with high EphrinB2 expression using sEphB4-HSA

  This study is testing a new treatment combining sEphB4-HSA with pembrolizumab to see if it helps people with advanced bladder cancer that has high levels of EphrinB2 feel better compared to standard chemotherapy.

  Recruiting Phase 2/3 Vasgene Therapeutics, Inc · Santa Monica, California · NCT06493552

• Combining enfortumab vedotin and pembrolizumab with radiation for muscle invasive bladder cancer

  This study is testing a new combination of a drug and radiation therapy to see if it helps people with muscle invasive bladder cancer who want to avoid surgery.

  Recruiting Phase 1/2 University of California, San Francisco · San Francisco, California · NCT06470282

• Bladder preservation approach for patients with muscle-invasive bladder cancer and variant histology

  This study is testing a new treatment plan for patients with a specific type of bladder cancer to see if combining chemotherapy and radiation can help them better than past treatments.

  Recruiting Phase 2 Cedars-Sinai Medical Center · Los Angeles, California · NCT06417190

• Neoadjuvant therapy for bladder cancer patients who can't tolerate cisplatin

  This study is testing a new combination of immune treatments for bladder cancer patients who can't take cisplatin to see if it helps them before surgery.

  Recruiting Phase 1/2 Zhujiang Hospital · Guangzhou, Guangdong · NCT06341400

• Combining futibatinib and durvalumab before bladder cancer surgery for patients who can't use cisplatin

  This study is testing if combining two drugs, futibatinib and durvalumab, before bladder cancer surgery can help patients who can't take cisplatin feel better and improve their chances of recovery.

  Recruiting at 2 sites Phase 2 Ohio State University Comprehensive Cancer Center · Ann Arbor, Michigan and 2 other locations · NCT06263153

• Observing quality of life in patients after bladder cancer surgery

  This study looks at how bladder cancer surgery affects the quality of life for patients over about 10 years by checking in with them each year.

  Recruiting IRCCS San Raffaele · Milan, MI · NCT06170177

• Combining targeted therapy with radiation for bladder cancer treatment

  This study is testing if a new targeted treatment combined with radiation can safely help people with muscle-invasive bladder cancer keep their bladders instead of needing surgery.

  Recruiting Phase 1 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT05833867

• Mindfulness and exercise program for bladder cancer surgery patients

  This study is testing a home program that combines exercise and mindfulness to help bladder cancer patients feel better and prepare for their surgery.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT05790850

• Collecting blood samples to evaluate tests for early cancer detection

  This study is collecting blood and tissue samples from people with and without cancer to see if new tests can help detect cancer earlier.

  Recruiting at 619 sites Alliance for Clinical Trials in Oncology · Anchorage, Alaska and 750 other locations · NCT05334069

• Evaluating outcomes of robotic surgery for bladder cancer

  This study is testing how well robotic surgery for bladder cancer works compared to traditional surgery by looking at patients' recovery and outcomes over time.

  Recruiting University of Florence · Florence, Tuscany · NCT04900558

• Evaluating the use of 18F-FDG-PET-CT for bladder cancer treatment decisions

  This study is testing whether special imaging can help doctors make better treatment decisions for patients with muscle invasive bladder cancer.

  Recruiting Phase 2 University Hospital, Ghent · Ghent · NCT04724928

Related topics

Quick answers

How many Muscle-Invasive Bladder Carcinoma clinical trials are recruiting right now?

18, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (11 trials), Italy (2 trials), Denmark (1 trial), France (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1/2: 3, Phase 1: 2, Phase 2/3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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