Condition

Metastatic Malignant Neoplasm in the Brain clinical trials and research

• 16Clinical trials
• 4Countries

Newest Metastatic Malignant Neoplasm in the Brain clinical trials

All recruiting trials (16)

• 64Cu-DOTA-Pembrolizumab PET to See If Treatment Is Working in Stage IV NSCLC

  This study tests a new PET imaging agent paired with pembrolizumab to see if it can show which tumors are still responding in adults with stage IV NSCLC who are already receiving pembrolizumab.

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT07619599

• Advanced MRI to distinguish recurrent brain tumor from radiation necrosis

  This trial tests whether advanced MRI scans (DR-CSI and sodium imaging) can tell if people with metastatic brain tumors have tumor recurrence or treatment-related radiation necrosis.

  Recruiting Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT07339085

• Imaging brain tumors using a targeted radioimmunoconjugate and PET scans

  This study is testing a new imaging method using a special drug to see if it can help identify immune cells in patients with brain tumors before they have surgery.

  Recruiting Phase 1 Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT06650163

• Using arginine with whole brain radiation therapy for brain metastases treatment

  This study is testing if taking arginine, either by mouth or through an IV, can help improve the effectiveness of whole brain radiation therapy for people with brain metastases.

  Recruiting Early Phase 1 Emory University · Atlanta, Georgia · NCT06328686

• Natural Killer Cell Therapy and Temozolomide for Stage IV Melanoma with Brain Metastasis

  This study is testing a new treatment combining special immune cells and a cancer drug to see if it helps people with advanced melanoma that has spread to the brain.

  Recruiting Phase 1/2 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT05588453

• Imaging HER2+ Breast Cancer with Brain Metastasis using a New Scan

  This study is testing a new type of scan to see if it can help doctors better understand how well a treatment works for people with HER2+ breast cancer that has spread to the brain.

  Recruiting Phase 4 City of Hope Medical Center · Duarte, California · NCT05376878

• Comparing single and fractionated stereotactic radiosurgery for brain metastases treatment

  This study is testing whether a single session of targeted radiation or multiple sessions is better for treating patients with brain tumors that have spread from other cancers.

  Recruiting at 6 sites Phase 2 Mayo Clinic · Scottsdale, Arizona and 6 other locations · NCT05222620

• Evaluating patient perceptions of telemedicine quality in neuro-oncology

  This study looks at how patients with brain tumors feel about the quality of care they get through telemedicine compared to in-person visits to see if there are any differences.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT04988009

• Comparing two treatment combinations for melanoma with brain metastases

  This study is testing two different treatment combinations for patients with melanoma that has spread to the brain to see which one helps them live longer without the disease getting worse.

  Recruiting at 303 sites Phase 2 SWOG Cancer Research Network · Birmingham, Alabama and 330 other locations · NCT04511013

• Dendritic cell vaccines and pembrolizumab for treating brain metastasis from breast cancer

  This study is testing a new vaccine combined with an immune therapy to see if it can help people with brain metastasis from triple negative or HER2+ breast cancer fight their cancer better.

  Recruiting at 2 sites Phase 2 Roswell Park Cancer Institute · Tampa, Florida and 2 other locations · NCT04348747

• Using microdialysis during brain surgery to collect biomarkers for tumors

  This study is testing if a special device used during brain surgery can help doctors collect important information about brain tumors to improve diagnosis and treatment for patients with these conditions.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT04047264

• Using targeted radiation therapy before or after surgery for brain tumors

  This study is testing whether giving targeted radiation therapy before or after surgery helps people with metastatic brain tumors live longer and have fewer side effects.

  Recruiting at 4 sites Phase 3 Mayo Clinic · Scottsdale, Arizona and 3 other locations · NCT03750227

• Using carvedilol to prevent heart problems in patients with advanced HER-2-positive breast cancer

  This study is testing if the heart medication carvedilol can help prevent heart problems in patients with advanced HER-2-positive breast cancer who are being treated with trastuzumab.

  Recruiting at 145 sites Phase 3 SWOG Cancer Research Network · Anchorage, Alaska and 589 other locations · NCT03418961

• Using gadolinium and ferumoxytol MRI to diagnose central nervous system abnormalities

  This study is testing if using two different MRI contrast agents, gadolinium and ferumoxytol, can help better diagnose problems in the central nervous system for patients with suspected abnormalities.

  Recruiting Phase 2 OHSU Knight Cancer Institute · Portland, Oregon · NCT03270059

• Evaluating brain function in patients with multiple brain tumors treated with targeted radiation

  This study is testing whether a specific type of radiation treatment for multiple brain tumors helps patients keep their thinking skills and quality of life better than another type of radiation.

  Recruiting Thomas Jefferson University · Sewell, New Jersey and 1 other locations · NCT03184038

• Mapping brain areas during surgery for brain tumors using electrocorticography

  This study is testing if a special brain monitoring technique during surgery can help doctors better identify important areas for movement and speech in patients with brain tumors.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT02754544

Related topics

Quick answers

How many Metastatic Malignant Neoplasm in the Brain clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (16 trials), Puerto Rico (1 trial), Saudi Arabia (1 trial), South Korea (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 3: 2, Phase 1: 2, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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