Mapping brain areas during surgery for brain tumors using electrocorticography
Official title: Pilot Investigation of Using Electrocorticogram (ECoG) in Predicting Eloquent Cortex and Post-Operative Functional Outcomes in Patients With Brain Tumors
Run by M.D. Anderson Cancer Center · NCT02754544 · Data updated 2026-11-12
This study is testing if a special brain monitoring technique during surgery can help doctors better identify important areas for movement and speech in patients with brain tumors.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 75 (estimated) |
| Sponsor | M.D. Anderson Cancer Center Academic / other |
| Locations | 1 site (Houston, Texas) |
| Status | Recruiting |
| Started | July 22, 2016 |
| Main results expected | January 1, 2027 |
| Study ends | January 1, 2028 |
| Registry record updated | November 10, 2026 |
| Trial ID | NCT02754544 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older undergoing tumor resection for newly diagnosed or recurrent brain tumors near motor or speech areas.
✕Probably not a fit
Patients with significant neurological deficits affecting motor or speech functions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This pilot clinical trial investigates the effectiveness of electrocorticography (ECoG) in identifying functional brain areas during surgery for patients with brain tumors. By utilizing advanced electrode grids, the study aims to enhance the mapping of brain activity related to motor and speech functions. Patients undergoing tumor resection will have ECoG data recorded during various tasks, which will be compared to existing pre-surgical mapping techniques. The study also seeks to assess the potential impact of ECoG on postoperative neurological and speech outcomes over time.
Why it matters
Potential benefit: If successful, this approach could lead to more precise tumor resections and improved functional outcomes for patients with brain tumors.
How similar studies have gone: Previous studies using electrocorticography for brain mapping have shown promising results, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing a tumor resection at the University of Texas M. D. Anderson Cancer Center for a newly diagnosed as well as recurrent primary or metastatic brain tumor located in or adjacent to motor and/or speech brain areas * Patients \>= 18 years of age * Signed informed consent Exclusion Criteria: * Patients with significant neurological motor deficits of the upper extremities, and/or speech deficits, which would preclude them from performing the while awake intra-operative tasks at the discretion of the principal investigator (PI) * Patients who have impaired vision and/or hearing and whose performance could affect the study will be excluded at the discretion of the PI
Where it's running
-
M D Anderson Cancer Center
Houston, Texas, United States Recruiting
Study contacts
- Principal investigator: Sujit S Prabhu — M.D. Anderson Cancer Center
- Study coordinator: Sujit Prabhu, MD
- Email: sprabhu@mdanderson.org
- Phone: 713-792-2400
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
64Cu-DOTA-Pembrolizumab PET to See If Treatment Is Working in Stage IV NSCLC
This study tests a new PET imaging agent paired with pembrolizumab to see if it can show which tumors are still responding in adults with stage IV NSCLC who are already receiving pembrolizumab.
-
Advanced MRI to distinguish recurrent brain tumor from radiation necrosis
This trial tests whether advanced MRI scans (DR-CSI and sodium imaging) can tell if people with metastatic brain tumors have tumor recurrence or treatment-related radiation necrosis.
-
Imaging brain tumors using a targeted radioimmunoconjugate and PET scans
This study is testing a new imaging method using a special drug to see if it can help identify immune cells in patients with brain tumors before they have surgery.
-
Using arginine with whole brain radiation therapy for brain metastases treatment
This study is testing if taking arginine, either by mouth or through an IV, can help improve the effectiveness of whole brain radiation therapy for people with brain metastases.
-
Natural Killer Cell Therapy and Temozolomide for Stage IV Melanoma with Brain Metastasis
This study is testing a new treatment combining special immune cells and a cancer drug to see if it helps people with advanced melanoma that has spread to the brain.
-
Imaging HER2+ Breast Cancer with Brain Metastasis using a New Scan
This study is testing a new type of scan to see if it can help doctors better understand how well a treatment works for people with HER2+ breast cancer that has spread to the brain.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.