Role of Prohibitin 1 in alcohol-related colorectal liver metastasis
Official title: The Role of Prohibitin 1 in Ethanol's Sensitizing Effect on Colorectal Liver Metastasis
Funded at Cedars-Sinai Medical Center · NIH-11413772 · Data updated 2026-11-12
This grant studies how a protein called PHB1 in liver cells affects cancer spread to the liver in people who drink alcohol.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 10, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $617,748 |
| NIH project number | 5R01AA032010-02 |
| Project ID | NIH-11413772 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with colorectal cancer at risk of liver metastasis, especially in the context of alcohol-related liver disease, may benefit from future targeted therapies.
✕Less likely to help
Patients without colorectal cancer or without liver metastasis risk may not benefit directly.
What this research studies
Researchers will look at how PHB1’s location inside liver cells (nucleus vs mitochondria) changes the progression of colorectal cancer spreading to the liver, especially with alcohol use. They will use mouse models and human tissue data to understand how PHB1 influences genes and signals like MMP-7 that control metastasis. The study will involve sequencing and molecular analyses to map PHB1’s interactions and how alcohol alters them. Findings could point to new ways to prevent or slow metastatic cancer in patients with alcohol-related liver disease.
Why it matters
Potential benefit: If successful, the work could lead to new strategies to prevent liver metastasis in patients with alcohol-related liver disease.
How similar studies have gone: Previous work suggests PHB1’s location affects its role in cancer, supporting the rationale for this study but human translation remains to be proven.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Lu, Shelly Chi-Loo — Cedars-Sinai Medical Center
- Study coordinator: Lu, Shelly Chi-Loo
Related research
Other NIH-funded projects on the same topics.
-
Lymph node metastasis and immune tolerance in head and neck cancer
A study in people with head and neck cancer looks at how cancer spread to lymph nodes may shape the immune system and help tumors grow.
-
Targeting how RMS cells fail to mature to slow or stop pediatric muscle cancer spread
A project to understand why a pediatric muscle cancer called rhabdomyosarcoma spreads, and to test ideas that could slow or stop it by helping cancer cells mature properly.
-
Centers studying how cancer spreads through the body
A multi-institutional project at Rockefeller University is exploring how nerves, blood vessels, lymphatics, immune cells, and metabolites influence the spread of cancer to help identify new ways to stop metastasis.
-
Angiopoietin-2 and Tie2 signals shaping liver metastasis in pancreatic neuroendocrine tumors
A study explores how Angiopoietin-2 and the Tie2 receptor influence the spread of pancreatic neuroendocrine tumors to the liver and how this affects responses to immunotherapy.
-
Nanoparticles that boost MRI to find tiny brain metastases
This uses tiny magnetic nanoparticles and new MRI image processing to help doctors find very small brain metastases earlier in people with cancer.
-
Tumor-Niche Co-evolution in Ovarian Cancer Metastasis and Resistance
This research explores how ovarian cancer cells interact with their surrounding tissue to understand how metastasis and resistance to therapy develop, with potential to guide better treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.