Condition

Metastatic Lung Cancer clinical trials and research

• 16Clinical trials
• 7NIH research projects
• 15Countries

Newest Metastatic Lung Cancer clinical trials

All recruiting trials (16)

• Does the time of day for PD-1/PD-L1 therapy affect response in NSCLC and HNSCC

  In people with advanced NSCLC or resectable head and neck cancer, this study tests whether receiving PD-1/PD-L1 therapy in the morning versus the afternoon changes treatment outcomes.

  Recruiting Phase 2 UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT07630168

• Combination immunotherapy and radiotherapy in metastatic non-small cell lung cancer

  This trial will test whether adding immunotherapy to radiotherapy helps people with metastatic non-small cell lung cancer who have progressed on prior immunotherapy.

  Recruiting Phase 2 University of Chicago · Chicago, Illinois · NCT07603856

• Long-term survivors of metastatic lung cancer: health, quality of life, and needs

  This project will follow people who have lived at least three years with metastatic lung cancer and are no longer on cytotoxic chemotherapy to see what their health, quality of life, and social needs are.

  Recruiting at 31 sites Groupe Francais De Pneumo-Cancerologie · Aix-en-Provence and 45 other locations · NCT07243132

• Thinking and mood changes from ALK/ROS1 targeted drugs in metastatic lung cancer and a patient-research care pathway

  This project will look at thinking, memory, and mood changes in adults in France taking ALK/ROS1-targeted drugs for metastatic lung cancer to see how these effects affect daily life and to build a patient-research care pathway.

  Recruiting at 2 sites Hospices Civils de Lyon · Bron and 1 other locations · NCT06781905

• Evaluating BBO-10203 for advanced solid tumors

  This study is testing a new treatment called BBO-10203, alone and with another drug, to see if it can help people with advanced solid tumors, including certain types of breast cancer.

  Recruiting at 43 sites Phase 1 TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics) · Duarte, California and 43 other locations · NCT06625775

• Pulsed radiotherapy with immunotherapy for metastatic non-small cell lung cancer that stopped responding to prior treatment

  This phase 1 study tests whether giving adaptive pulsed radiotherapy together with PD-(L)1 inhibitors is safe and can help people with metastatic NSCLC whose cancer has progressed on immunotherapy.

  Recruiting Phase 1 Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT06622174

• Ongoing collection of blood and tumor samples from people with lung cancer

  Collect and store blood and tumor samples over time from adults with newly diagnosed or metastatic lung cancer to build a real-world biobank for research.

  Recruiting Nantes University Hospital · Angers and 3 other locations · NCT06481813

• Evaluating BBO-8520 for treating KRAS G12C non-small cell lung cancer

  This study is testing a new drug called BBO-8520 to see if it can safely help adults with a specific type of lung cancer that has a KRAS G12C mutation, both on its own and when combined with another treatment.

  Recruiting at 38 sites Phase 1 TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics) · Birmingham, Alabama and 37 other locations · NCT06343402

• Radiation treatment for high-risk spine cancer patients

  This study is testing a new type of radiation treatment for patients with cancer that has spread to the spine to see if it can help manage their condition without needing major surgery.

  Recruiting Phase 2 Stony Brook University · Stony Brook, New York · NCT06165419

• Investigating OBX-115 for advanced solid tumors

  This study is testing a new treatment called OBX-115 to see if it can help adults with advanced solid tumors like metastatic melanoma and non-small cell lung cancer feel better and live longer.

  Recruiting at 13 sites Phase 1/2 Obsidian Therapeutics, Inc. · Tucson, Arizona and 13 other locations · NCT06060613

• Single-drug chemotherapy combined with immunotherapy for elderly patients with metastatic lung cancer

  This study is testing if combining a single-drug chemotherapy with immunotherapy can help older patients with advanced lung cancer live longer and feel better compared to just using traditional chemotherapy.

  Recruiting Phase 2 Hubei Cancer Hospital · Wuhan, Hubei · NCT06032052

• Evaluating the effects of radiotherapy on patients with oligometastatic cancer

  This study is testing how well Stereotactic Ablative Radiotherapy (SABR) works for people with oligometastatic cancer to see if it can help them live longer and feel better.

  Recruiting Institut Investigacio Sanitaria Pere Virgili · Albacete, Albacete and 20 other locations · NCT05933876

• Evaluating BDTX-4933 for patients with specific cancer mutations

  This study is testing a new drug called BDTX-4933 to see if it can help adults with advanced cancers that have certain gene mutations feel better and improve their treatment options.

  Recruiting at 34 sites Phase 1/2 Servier · Gilbert, Arizona and 48 other locations · NCT05786924

• Immunotherapy for advanced metastatic solid tumors

  This study is testing a new immunotherapy called SYNC-T to see if it can help people with advanced solid tumors that haven't responded to other treatments.

  Recruiting Phase 1 Williams Cancer Foundation · Mexico City · NCT05544240

• Fecal microbiota transplant combined with immune therapy for lung cancer

  This study is testing whether a fecal transplant from healthy donors can help improve the effectiveness of immune therapy in people with advanced lung cancer.

  Recruiting Phase 2 Soroka University Medical Center · Beersheba and 1 other locations · NCT05502913

• Using liquid biopsy to predict responses to immunotherapy in metastatic lung cancer

  This study is testing if measuring tumor DNA in the blood can help predict how well new immunotherapy treatments work for people with advanced lung cancer who haven't started treatment yet.

  Recruiting at 3 sites Institut Curie · Boulogne-Billancourt and 2 other locations · NCT04790682

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• ECM-targeted theranostic treatment for metastatic lung cancer

  A new therapy aims to deliver cancer-fighting agents directly to the tumor environment in people with metastatic lung cancer.

  NIH research Matrisome Bio, INC. · Cambridge, UNITED STATES · NIH-11419641

• Targeted T cell therapy for metastatic lung cancer with mutated KRAS

  A personalized therapy uses engineered T cells to attack KRAS-mutated metastatic non-small cell lung cancer in patients.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11397778

• Supportive Care for Lung Cancer Patients with Targeted Therapy

  A patient-facing program tests a palliative care approach tailored for people living with oncogene-driven metastatic lung cancer to help with uncertainty, self-care, and discussions about goals and values.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11395321

• LiveWell — DBT skills training for people living with metastatic lung cancer

  This is an eight-session, one-on-one online program that teaches Dialectical Behavior Therapy skills to help people living with metastatic lung cancer handle distress, symptoms, and relationships.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11386709

• Engineered T cells that target KRAS-mutated metastatic lung cancer

  This project uses specially engineered immune cells to try to find and kill metastatic lung cancers that have KRAS gene mutations.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11196687

• Using aerosolized therapy to treat metastatic lung cancer

  This study is exploring a new way to treat metastatic lung cancer by using a special inhaled therapy that may help wake up genes in cancer cells, and it's designed for patients looking for more effective treatment options.

  NIH research Nob Hill Therapeutics, INC. · Albuquerque, UNITED STATES · NIH-10931496

• Improving care for patients with advanced lung cancer using personalized approaches

  This study is looking to improve support for people with metastatic lung cancer who have certain genetic mutations by testing a new way to help them feel more comfortable and make better decisions about their care, based on what they and their doctors think is important.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10910885

Related topics

Quick answers

How many Metastatic Lung Cancer clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 15 countries. The most sites are in United States (7 trials), France (6 trials), Spain (4 trials), Australia (4 trials), China (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1: 4, Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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