Clinical trial Recruiting at 1 site Observational Ages 18 and up

Evaluating the effects of radiotherapy on patients with oligometastatic cancer

Official title: Stereotactic ABlative Radiotherapy (SABR) in Oligometastatic Cancer (OC): a Radiomics, Multi-omics, and Machine Learning Approach to Clinical Decision-making. the OC-SABR Multicentric Project

Run by Institut Investigacio Sanitaria Pere Virgili · NCT05933876 · Data updated 2026-11-12

This study is testing how well Stereotactic Ablative Radiotherapy (SABR) works for people with oligometastatic cancer to see if it can help them live longer and feel better.

More Metastasis trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment2000 (estimated)
SponsorInstitut Investigacio Sanitaria Pere Virgili
Academic / other
Locations21 sites (Albacete, Albacete and 20 other locations)
StatusRecruiting
StartedDecember 1, 2022
Main results expectedDecember 31, 2037
Study endsDecember 31, 2037
Registry record updatedNovember 18, 2024
Trial IDNCT05933876 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and older with histologically confirmed metastatic breast, prostate, lung, or colorectal cancer and up to five metastases.

Probably not a fit

Patients with non-melanoma skin cancer, previous radiotherapy in the same area, or those with vascular collagen disease may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the impact of Stereotactic ABlative Radiotherapy (SABR) on patients with oligometastatic cancer, which is characterized by a limited number of metastases. By collecting clinical data, medical images, and biological samples from multiple centers, the study seeks to identify patient profiles that respond favorably to SABR. The research will utilize artificial intelligence to analyze this data and predict which patients are most likely to benefit from the treatment, ultimately aiming to improve survival rates and quality of life for these patients.

Why it matters

Potential benefit: If successful, this study could lead to personalized treatment strategies that significantly enhance survival rates for patients with oligometastatic cancer.

How similar studies have gone: While there have been few studies on SABR for oligometastatic cancer, the approach of using multi-omics data and artificial intelligence to personalize treatment is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Histologic confirmation of primary tumor: breast, prostate, lung, colorectal.
* 18 years old or older.
* Up to five metastases located in the bone, lung, node, liver or brain.
* Eastern Cooperative Oncology Group (ECOG) Performance Status Scale 0 or 1.

Exclusion Criteria:

* Non-melanoma skin cancer.
* Previous radiotherapy in the same anatomic location.
* Presence of vascular collagen disease.
* Pregnancy or lactation at the time of inclusion.

Where it's running

  • Hospital Universitari Sant Joan de Reus
    Reus, Tarragona, Spain
    Recruiting
  • Complejo Hospitalario Universitario Albacete
    Albacete, Albacete, Spain
    Not yet recruiting
  • Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
    Barcelona, Barcelona, Spain
    Not yet recruiting
  • Hospital Universitari Vall d'Hebron
    Barcelona, Barcelona, Spain
    Not yet recruiting
  • Institut Català d'Oncologia
    Barcelona, Barcelona, Spain
    Not yet recruiting
  • Hospital Universitario Virgen de las Nieves
    Granada, Granada, Spain
    Not yet recruiting
Show 15 more locations
  • Hospital Universitari Arnau de Vilanova
    Lleida, Lleida, Spain
    Not yet recruiting
  • Hospital de La Luz
    Madrid, Madrid, Spain
    Not yet recruiting
  • Hospital Ruber Internacional
    Madrid, Madrid, Spain
    Not yet recruiting
  • Hospital Universitario HM Sanchinarro
    Madrid, Madrid, Spain
    Not yet recruiting
  • Hospital Universitario Quirónsalud
    Madrid, Madrid, Spain
    Not yet recruiting
  • Hospital Universitario Rey Juan Carlos
    Madrid, Madrid, Spain
    Not yet recruiting
  • Hospital Universitario Virgen Macarena
    Seville, Sevilla, Spain
    Not yet recruiting
  • Hospital Clínico Universitario de Valencia
    Valencia, Valencia, Spain
    Not yet recruiting
  • Hospital General Univesitario de Valencia
    Valencia, Valencia, Spain
    Not yet recruiting
  • Hospital Universitari Miguel Servet
    Zaragoza, Zaragoza, Spain
    Not yet recruiting
  • Hospital del Mar
    Barcelona, Spain
    Not yet recruiting
  • Hospital Provincial de Castellón
    Castellon, Spain
    Not yet recruiting
  • Institut Català d'Oncologia
    Girona, Spain
    Not yet recruiting
  • Hospital Universitario Ramón y Cajal
    Madrid, Spain
    Not yet recruiting
  • Hospital de Terrassa
    Terrassa, Spain
    Not yet recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.