Evaluating the effects of radiotherapy on patients with oligometastatic cancer
Official title: Stereotactic ABlative Radiotherapy (SABR) in Oligometastatic Cancer (OC): a Radiomics, Multi-omics, and Machine Learning Approach to Clinical Decision-making. the OC-SABR Multicentric Project
Run by Institut Investigacio Sanitaria Pere Virgili · NCT05933876 · Data updated 2026-11-12
This study is testing how well Stereotactic Ablative Radiotherapy (SABR) works for people with oligometastatic cancer to see if it can help them live longer and feel better.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 2000 (estimated) |
| Sponsor | Institut Investigacio Sanitaria Pere Virgili Academic / other |
| Locations | 21 sites (Albacete, Albacete and 20 other locations) |
| Status | Recruiting |
| Started | December 1, 2022 |
| Main results expected | December 31, 2037 |
| Study ends | December 31, 2037 |
| Registry record updated | November 18, 2024 |
| Trial ID | NCT05933876 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older with histologically confirmed metastatic breast, prostate, lung, or colorectal cancer and up to five metastases.
✕Probably not a fit
Patients with non-melanoma skin cancer, previous radiotherapy in the same area, or those with vascular collagen disease may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess the impact of Stereotactic ABlative Radiotherapy (SABR) on patients with oligometastatic cancer, which is characterized by a limited number of metastases. By collecting clinical data, medical images, and biological samples from multiple centers, the study seeks to identify patient profiles that respond favorably to SABR. The research will utilize artificial intelligence to analyze this data and predict which patients are most likely to benefit from the treatment, ultimately aiming to improve survival rates and quality of life for these patients.
Why it matters
Potential benefit: If successful, this study could lead to personalized treatment strategies that significantly enhance survival rates for patients with oligometastatic cancer.
How similar studies have gone: While there have been few studies on SABR for oligometastatic cancer, the approach of using multi-omics data and artificial intelligence to personalize treatment is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Histologic confirmation of primary tumor: breast, prostate, lung, colorectal. * 18 years old or older. * Up to five metastases located in the bone, lung, node, liver or brain. * Eastern Cooperative Oncology Group (ECOG) Performance Status Scale 0 or 1. Exclusion Criteria: * Non-melanoma skin cancer. * Previous radiotherapy in the same anatomic location. * Presence of vascular collagen disease. * Pregnancy or lactation at the time of inclusion.
Where it's running
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Hospital Universitari Sant Joan de Reus
Reus, Tarragona, Spain Recruiting -
Complejo Hospitalario Universitario Albacete
Albacete, Albacete, Spain Not yet recruiting -
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Barcelona, Barcelona, Spain Not yet recruiting -
Hospital Universitari Vall d'Hebron
Barcelona, Barcelona, Spain Not yet recruiting -
Institut Català d'Oncologia
Barcelona, Barcelona, Spain Not yet recruiting -
Hospital Universitario Virgen de las Nieves
Granada, Granada, Spain Not yet recruiting
Show 15 more locations
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Hospital Universitari Arnau de Vilanova
Lleida, Lleida, Spain Not yet recruiting -
Hospital de La Luz
Madrid, Madrid, Spain Not yet recruiting -
Hospital Ruber Internacional
Madrid, Madrid, Spain Not yet recruiting -
Hospital Universitario HM Sanchinarro
Madrid, Madrid, Spain Not yet recruiting -
Hospital Universitario Quirónsalud
Madrid, Madrid, Spain Not yet recruiting -
Hospital Universitario Rey Juan Carlos
Madrid, Madrid, Spain Not yet recruiting -
Hospital Universitario Virgen Macarena
Seville, Sevilla, Spain Not yet recruiting -
Hospital Clínico Universitario de Valencia
Valencia, Valencia, Spain Not yet recruiting -
Hospital General Univesitario de Valencia
Valencia, Valencia, Spain Not yet recruiting -
Hospital Universitari Miguel Servet
Zaragoza, Zaragoza, Spain Not yet recruiting -
Hospital del Mar
Barcelona, Spain Not yet recruiting -
Hospital Provincial de Castellón
Castellon, Spain Not yet recruiting -
Institut Català d'Oncologia
Girona, Spain Not yet recruiting -
Hospital Universitario Ramón y Cajal
Madrid, Spain Not yet recruiting -
Hospital de Terrassa
Terrassa, Spain Not yet recruiting
Study contacts
- Study coordinator: Jorge Joven, Prof.
- Email: jorge.joven@urv.cat
- Phone: +34977310300
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.