Investigating lymph node metastasis in pancreatic cancer surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the incidence and clinical implications of para-aortic lymph node (PALN) metastasis in patients undergoing curative resection for pancreatic cancer. By systematically resecting PALNs during surgery, the study seeks to clarify whether these nodes should be considered regional or indicative of systemic disease. The primary outcome focuses on determining the incidence of PALN metastasis, while secondary outcomes include evaluating the prognosis of patients with such metastasis and the incidence of metastasis in regional lymph nodes. The findings could influence surgical approaches and treatment strategies for pancreatic cancer.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Resectable suspected periampullary cancer (requiring duodenopancreatectomy) (NCCN guidelines 2020)

Borderline resectable periampullary cancer (requiring duodenopancreatectomy) (NCCN guidelines 2020)

Age \>18 years

Written patient consent

Exclusion Criteria:

Contraindication for a radical resection procedure

Unresectable tumor (NCCN guidelines 2020) or metastatic disease (lgll station 16 not included)

Mental or organic disorders which could interfere with giving informed consent or receiving treatments

Where it's running

• Norrland University Hospital
  Umeå, Sweden Recruiting
• Uppsala University Hospital
  Uppsala, Sweden Recruiting
• Odense University Hospital
  Odense, Denmark Not yet recruiting
• Sahlgrenska university hospital
  Gothenburg, Sweden Active not recruiting
• Linköping University Hospital
  Linköping, Sweden Active not recruiting
• Skåne University Hospital
  Lund, Sweden Active not recruiting

Study contacts

• Principal investigator: Britt-Marie Karlson — Uppsala University Hospital
• Study coordinator: Christopher Månsson
• Email: Christopher.mansson@akademiska.se
• Phone: 0186110000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.