Clinical trial Recruiting at 1 site Observational Ages 18 and up

Investigating the Role of Lymph Nodes in Lung Cancer with Pleural Invasion

Official title: Role of Intrapulmonary Lymph Nodes in Patients With NSCLC and Visceral Pleural Invasion

Run by Luzerner Kantonsspital · NCT05596578 · Data updated 2026-11-12

This study is trying to see if checking certain lymph nodes can help doctors better understand and treat patients with non-small cell lung cancer that has spread to the pleura.

More Lung Cancer trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment958 (estimated)
SponsorLuzerner Kantonsspital
Academic / other
Locations1 site (Lucerne)
StatusRecruiting
StartedJanuary 1, 2023
Main results expectedDecember 31, 2024
Study endsDecember 31, 2029
Registry record updatedJanuary 9, 2023
Trial IDNCT05596578 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients undergoing anatomical resection for NSCLC tumors smaller than 3 cm with visceral pleural invasion.

Probably not a fit

Patients with prior lung cancer, advanced disease (pN2 or M1), or those who have undergone neoadjuvant treatment may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the significance of intrapulmonary lymph nodes in patients diagnosed with non-small cell lung cancer (NSCLC) who have visceral pleural invasion. It focuses on understanding whether the dissection of specific lymph nodes is necessary for accurate staging and treatment planning. The study will analyze samples from lymph node stations 12, 13, and 14 to assess their prognostic value. The research seeks to clarify the controversial impact of visceral pleural invasion on patient outcomes.

Why it matters

Potential benefit: If successful, this study could improve staging accuracy and treatment strategies for patients with NSCLC, potentially leading to better outcomes.

How similar studies have gone: While the significance of lymph node dissection in NSCLC is debated, this specific approach to studying intrapulmonary lymph nodes is relatively novel and has not been extensively tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Anatomical resection for NSCLC \<3 cm (lobectomy, bilobectomy, segmentectomy)
* Samples from the intrapulmonary stations 12, 13, and 14 lymph nodes
* Resection of lymphnodes station 10 and 11 during hilar separation.
* R0 resection

Exclusion Criteria:

* Prior or synchronous lung cancer
* pN2
* Pneumonectomy
* R1/R2 resection
* M1
* Neoadjuvant treatment

Where it's running

  • Kantonsspital Luzern
    Lucerne, Switzerland
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.