Investigating the Role of Lymph Nodes in Lung Cancer with Pleural Invasion
Official title: Role of Intrapulmonary Lymph Nodes in Patients With NSCLC and Visceral Pleural Invasion
Run by Luzerner Kantonsspital · NCT05596578 · Data updated 2026-11-12
This study is trying to see if checking certain lymph nodes can help doctors better understand and treat patients with non-small cell lung cancer that has spread to the pleura.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 958 (estimated) |
| Sponsor | Luzerner Kantonsspital Academic / other |
| Locations | 1 site (Lucerne) |
| Status | Recruiting |
| Started | January 1, 2023 |
| Main results expected | December 31, 2024 |
| Study ends | December 31, 2029 |
| Registry record updated | January 9, 2023 |
| Trial ID | NCT05596578 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients undergoing anatomical resection for NSCLC tumors smaller than 3 cm with visceral pleural invasion.
✕Probably not a fit
Patients with prior lung cancer, advanced disease (pN2 or M1), or those who have undergone neoadjuvant treatment may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to evaluate the significance of intrapulmonary lymph nodes in patients diagnosed with non-small cell lung cancer (NSCLC) who have visceral pleural invasion. It focuses on understanding whether the dissection of specific lymph nodes is necessary for accurate staging and treatment planning. The study will analyze samples from lymph node stations 12, 13, and 14 to assess their prognostic value. The research seeks to clarify the controversial impact of visceral pleural invasion on patient outcomes.
Why it matters
Potential benefit: If successful, this study could improve staging accuracy and treatment strategies for patients with NSCLC, potentially leading to better outcomes.
How similar studies have gone: While the significance of lymph node dissection in NSCLC is debated, this specific approach to studying intrapulmonary lymph nodes is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Anatomical resection for NSCLC \<3 cm (lobectomy, bilobectomy, segmentectomy) * Samples from the intrapulmonary stations 12, 13, and 14 lymph nodes * Resection of lymphnodes station 10 and 11 during hilar separation. * R0 resection Exclusion Criteria: * Prior or synchronous lung cancer * pN2 * Pneumonectomy * R1/R2 resection * M1 * Neoadjuvant treatment
Where it's running
-
Kantonsspital Luzern
Lucerne, Switzerland Recruiting
Study contacts
- Study coordinator: Fabrizio Minervini, MD, PhD
- Email: fabriziominervini@hotmail.com
- Phone: +410412051111
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.