How lymph node metastasis affects the body's immune response to tumors
The influence of lymph node metastasis on local and systemic anti-tumor immunity
This study is looking at how cancer spreading to lymph nodes affects the body's immune response, especially in people with melanoma and other solid tumors, to find new ways to boost the immune system's ability to fight cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10996877 on NIH RePORTER |
What this research studies
This research investigates the role of lymph node metastasis in melanoma and other solid tumors, focusing on how it influences both local and systemic anti-tumor immunity. The study aims to understand the mechanisms by which lymph nodes, previously thought to be passive in metastasis, may actually contribute to immune suppression that allows cancer to spread. By utilizing advanced techniques like single-cell and spatial transcriptomics, researchers will create a detailed map of lymph node changes during metastasis. This could lead to new insights into how to enhance immune responses in patients with intact tumor-draining lymph nodes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with melanoma or other solid tumors that have lymph node metastasis.
Not a fit: Patients with early-stage tumors that have not spread to lymph nodes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that enhance the immune system's ability to fight tumors in patients with lymph node metastasis.
How similar studies have performed: Other research has shown promising results in understanding immune responses in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Ventre, Katherine — New York University School of Medicine
- Study coordinator: Ventre, Katherine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.