Factors from a gut bacterium that affect kidney stone formation
Official title: Oxalobacter formigenes-derived Factors Impact Hyperoxalemia, Hyperoxaluria, and Related Kidney Stones
Funded at Mayo Clinic Rochester · NIH-10661844 · Data updated 2026-11-12
This study is looking at how a friendly gut bacterium can help lower the amount of oxalate in urine, which can lead to kidney stones, and it’s for anyone who wants to find new ways to prevent these painful stones from forming.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $349,800 |
| NIH project number | 5R01DK121204-04 |
| Project ID | NIH-10661844 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who experience recurrent kidney stones, particularly those with high urinary oxalate levels.
✕Less likely to help
Patients who do not have a history of kidney stones or those whose condition is unrelated to oxalate levels may not benefit from this research.
What this research studies
This research investigates how factors derived from the gut bacterium Oxalobacter formigenes can influence the levels of oxalate in urine, which is a key contributor to kidney stone formation. The study aims to identify specific substances produced by this bacterium that can enhance the secretion of oxalate from the colon, thereby reducing urinary oxalate levels. By using a combination of laboratory cell cultures and animal models, the researchers will assess the effectiveness of these factors in lowering the risk of kidney stones. The ultimate goal is to develop a new therapeutic approach to prevent kidney stones, which are a common and painful condition.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the risk of kidney stones for patients prone to this condition.
How similar studies have gone: Other research has shown promise in using gut bacteria to influence metabolic processes, suggesting that this approach could be viable.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Hassan, Hatim a — Mayo Clinic Rochester
- Study coordinator: Hassan, Hatim a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.