Negative-pressure suction during flexible ureteroscopy to reduce fluid absorption and infections
Impact of Negative Pressure Suction on Irrigation Fluid Absorption and Postoperative Infection Risk During Flexible Ureteroscopic Lithotripsy: A Prospective Cohort Study
This test will see if using a negative-pressure suction sheath during retrograde intrarenal surgery for adults with kidney stones reduces how much irrigation fluid their bodies absorb and lowers the risk of postoperative infections.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Lanzhou University Second Hospital Academic / other |
| Locations | 1 site (Lanzhou, Gansu) |
| Trial ID | NCT07492147 on ClinicalTrials.gov |
What this trial studies
This is an observational comparison of patients undergoing retrograde intrarenal surgery (RIRS) with a negative-pressure suction sheath versus a standard sheath without suction. Researchers will collect routine clinical data from adults (18+) treated at the hospital to measure irrigation fluid absorption and postoperative infection outcomes such as fever, SIRS, and urosepsis. No experimental interventions are added—the surgeries occur as part of usual care and data are recorded from medical records. The goal is to determine whether suction technology is associated with lower fluid absorption and fewer infectious complications.
Who should consider this trial
Good fit: Adults aged 18 or older with kidney stones who are scheduled for RIRS and can give informed consent are the intended participants.
Not a fit: Patients undergoing combined procedures, with untreated urinary tract infections, certain malignancies, congenital renal anomalies, severe organ dysfunction, or other listed exclusions are unlikely to be eligible or to receive benefit from the findings.
Why it matters
Potential benefit: If successful, using a suction sheath during RIRS could reduce the amount of fluid absorbed and lower the chance of postoperative infections for patients.
How similar studies have performed: Some prior small studies and device reports suggest suction during ureteroscopy can lower intrarenal pressure and bacteremia, but large confirmatory data are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 years and older with kidney stones who meet the surgical indications for RIRS; * Patients who have provided informed consent. Exclusion Criteria: * Concurrent combination with other surgical procedures, such as percutaneous nephrolithotomy (PCNL); * Patients with malignancies, urinary tuberculosis, immune system diseases, or hyperthyroidism; * Congenital renal anomalies, such as polycystic kidney disease or horseshoe kidney; * Presence of untreated urinary tract infections; * Inability to tolerate surgery due to severe cardiopulmonary dysfunction, hepatic or renal insufficiency, or coagulation abnormalities.
Where this trial is running
Lanzhou, Gansu
- Lanzhou University Second Hospital — Lanzhou, Gansu, China (Recruiting)
Study contacts
- Study coordinator: Zhiping Wang
- Email: wangzplzu@163.com
- Phone: 13893131697
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.