Effectiveness of medications to prevent kidney stones
Official title: Real-world effectiveness of preventive pharmacological therapy for patients with kidney stones
Funded at University of Michigan at Ann Arbor · NIH-10833141 · Data updated 2026-11-12
This study is looking at how well medications like thiazide diuretics and allopurinol can help people who have had kidney stones avoid getting them again, focusing on real-life results that matter to you, like fewer painful episodes and trips to the emergency room.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | April 1, 2020 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $546,833 |
| NIH project number | 5R01DK121709-05 |
| Project ID | NIH-10833141 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 21 and older who have a history of kidney stones and are at risk of recurrence.
✕Less likely to help
Patients who have never had kidney stones or those with conditions that contraindicate the use of the studied medications may not benefit from this research.
What this research studies
This research investigates how effective certain medications, like thiazide diuretics and allopurinol, are in preventing kidney stones from recurring. It aims to fill gaps in existing knowledge by focusing on real-world outcomes that matter to patients, such as reducing painful episodes that lead to emergency visits or surgeries. The study will analyze large datasets to assess the long-term benefits and costs associated with these preventive treatments, providing insights into their tolerability and overall effectiveness.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies for kidney stones, reducing pain and healthcare costs for patients.
How similar studies have gone: Previous research has shown promise in using preventive pharmacological therapies for kidney stones, but this study aims to provide more comprehensive real-world data.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Shahinian, Vahakn B — University of Michigan at Ann Arbor
- Study coordinator: Shahinian, Vahakn B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.