Condition

Intracranial Atherosclerosis clinical trials and research

• 10Clinical trials
• 5NIH research projects
• 1New in 30 days
• 4Countries

Newest Intracranial Atherosclerosis clinical trials

All recruiting trials (10)

• Brain recovery after MCA reopening is studied with PET/MR

  This study tests how brain blood flow, metabolism, and networks change after reopening a non-acute atherosclerotic middle cerebral artery occlusion in adults receiving recanalization treatment.

  Recruiting Qianfoshan Hospital · Jinan, Shandong · NCT07927569

• Dulaglutide for improving blood flow in severe intracranial artery narrowing

  This trial will test whether dulaglutide can improve cerebral blood flow reserve in adults who recently had a TIA or mild ischemic stroke from severe narrowing of the intracranial carotid or middle cerebral artery.

  Recruiting Phase 2/3 National University of Singapore · Singapore · NCT07282041

• PCSK9 inhibitor plus statin for reversing asymptomatic intracranial artery plaque

  This trial will test whether adding a PCSK9 inhibitor to statin therapy can shrink plaque and improve narrowing in adults aged 18–60 with asymptomatic intracranial artery stenosis (≥50%).

  Recruiting at 2 sites Phase 4 Peking Union Medical College Hospital · Beijing, Beijing Municipality and 18 other locations · NCT06902740

• Genotype-guided P2Y12 inhibitor selection versus standard clopidogrel for symptomatic intracranial atherosclerosis

  This test will see if using a point-of-care CYP2C19 genetic test to guide whether people who recently had a TIA or ischemic stroke from intracranial atherosclerosis should take ticagrelor plus aspirin instead of standard clopidogrel plus aspirin to lower the chance of another stroke.

  Recruiting Sunnybrook Health Sciences Centre · Calgary, Alberta and 1 other locations · NCT06714526

• Screening for intracranial atherosclerosis using fundus imaging

  This study is testing if a simple eye exam can help find early signs of a serious condition that causes strokes in people, especially in the Asian population.

  Recruiting Xuanwu Hospital, Beijing · Beijing, None Selected · NCT06610578

• Comparing stenting and conventional treatment for stroke patients with blocked arteries

  This study is testing if early stenting can help stroke patients with blocked arteries feel better compared to standard treatments when their initial therapy hasn't worked.

  Recruiting University Hospital, Basel, Switzerland · Basel, Canton of Basel-City · NCT06472336

• Exploring cognitive decline in patients with narrowed brain arteries

  This study looks at how narrowed brain arteries affect thinking and memory in people with symptoms to see what might be causing their cognitive decline.

  Recruiting Anhui Medical University · Hefei, Anhui · NCT06336174

• Using high-resolution MRI to study brain artery plaques in stroke patients

  This study is testing how high-resolution MRI can help understand the plaque in brain arteries of stroke patients to find better ways to prevent future strokes.

  Recruiting General Hospital of Shenyang Military Region · Shenyang · NCT05897645

• Evaluating a new stent for treating narrowed brain arteries

  This study is testing a new stent for people with narrowed brain arteries to see if it works better and is safer than an existing stent.

  Recruiting at 7 sites Ton-Bridge Medical Tech. Co., Ltd · Luoyang, Henan and 12 other locations · NCT05757505

• Using Optical Coherence Tomography to Evaluate Intracranial Atherosclerosis

  This study is testing whether a special imaging technique can help doctors better understand and treat narrowing of brain arteries in patients at risk for strokes.

  Recruiting Xuanwu Hospital, Beijing · Beijing, Beijing Municipality · NCT05550077

NIH-funded research (5)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How low blood flow after brain artery narrowing affects the vessel lining

  This work looks at whether areas of low blood flow downstream of narrowed brain arteries cause vessel lining damage and raise the chance of another stroke, for people with intracranial artery narrowing.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11504591

• Platelet markers and blood flow to predict recurrent stroke in intracranial artery disease

  Researchers will look at how a platelet protein (FcγRIIa) and blood flow patterns from CT angiography predict who might have another stroke after a minor stroke or TIA caused by intracranial artery disease.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11504575

• Investigating how low shear stress affects blood vessel health in brain artery disease

  This study is looking at how low blood flow in the brain's arteries can lead to a condition called intracranial atherosclerosis, and it's for people who want to understand their risk of having another stroke; the researchers hope to find clues that could help create better treatments.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11134234

• Using platelet markers and blood flow analysis to predict stroke recurrence in patients with narrowed arteries

  This study is looking at how certain markers in your blood and how blood flows in your arteries can help predict if you might have another stroke after experiencing a minor stroke or TIA, and it's for people who have recently had these types of strokes.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11049115

• Using advanced MRI to predict treatment response in patients with brain artery disease

  This study is looking at how special MRI scans can help us see changes in the fatty deposits in the brain's arteries, so we can better understand which patients might need different treatments for their condition.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-10579278

Related topics

Quick answers

How many Intracranial Atherosclerosis clinical trials are recruiting right now?

10, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in China (7 trials), Singapore (1 trial), Switzerland (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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