Using platelet markers and blood flow analysis to predict stroke recurrence in patients with narrowed arteries
Platelet Expression of FcgammaRIIa and Arterial Hemodynamics to Predict Recurrent Stroke in Intracranial Atherosclerosis
This study is looking at how certain markers in your blood and how blood flows in your arteries can help predict if you might have another stroke after experiencing a minor stroke or TIA, and it's for people who have recently had these types of strokes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11049115 on NIH RePORTER |
What this research studies
This research investigates how specific markers on platelets and the flow of blood in arteries can help predict the risk of recurrent strokes in patients who have experienced a minor stroke or transient ischemic attack (TIA) due to intracranial atherosclerosis. By analyzing patient-specific CT angiography and computational fluid dynamics, the study aims to develop a precision model that quantifies the risk of future ischemic events. The research will involve recruiting a diverse group of 250 participants who have recently suffered from acute cerebral ischemia, allowing for a comprehensive understanding of the factors contributing to stroke recurrence.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a minor stroke or TIA due to significant narrowing of the arteries in the brain.
Not a fit: Patients who have not experienced a stroke or TIA, or those with other unrelated medical conditions, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing recurrent strokes in at-risk patients.
How similar studies have performed: Previous research has shown promising results in using platelet markers and blood flow analysis to predict cardiovascular events, indicating that this approach may be effective.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Liebeskind, David Sigmund — University of California Los Angeles
- Study coordinator: Liebeskind, David Sigmund
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.