Using platelet markers and blood flow analysis to predict stroke recurrence in patients with narrowed arteries

Who could benefit from this research

What this research studies

This research investigates how specific markers on platelets and the flow of blood in arteries can help predict the risk of recurrent strokes in patients who have experienced a minor stroke or transient ischemic attack (TIA) due to intracranial atherosclerosis. By analyzing patient-specific CT angiography and computational fluid dynamics, the study aims to develop a precision model that quantifies the risk of future ischemic events. The research will involve recruiting a diverse group of 250 participants who have recently suffered from acute cerebral ischemia, allowing for a comprehensive understanding of the factors contributing to stroke recurrence.

Why it matters

Where this research is happening

• University of California Los Angeles
  Los Angeles, United States Active

Researchers

• Principal investigator: Liebeskind, David Sigmund — University of California Los Angeles
• Study coordinator: Liebeskind, David Sigmund

Related research

Other NIH-funded projects on the same topics.

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• Investigating how low shear stress affects blood vessel health in brain artery disease

  This study is looking at how low blood flow in the brain's arteries can lead to a condition called intracranial atherosclerosis, and it's for people who want to understand their risk of having another stroke; the researchers hope to find clues that could help create better treatments.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11134234

• Understanding how blood flow affects clot formation and stroke risk in carotid webs

  This study is looking at how blood flows in the carotid artery of people with carotid webs, which can lead to strokes, to help understand what causes clots to form and improve treatment for those affected.

  NIH research Emory University · Atlanta, United States · NIH-11120019

• Understanding brain blood flow changes in HIV-related TB meningitis and stroke.

  This study is looking at how tuberculous meningitis affects blood flow in the brain and the risk of stroke for people living with HIV, using special imaging techniques to better understand these changes and their impact on long-term brain health.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10892287

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.