Screening for intracranial atherosclerosis using fundus imaging

Intracranial Atherosclerosis Screen Based on Retinal Imaging Characteristic

This study is testing if a simple eye exam can help find early signs of a serious condition that causes strokes in people, especially in the Asian population.

Quick facts

• Study type: Observational
• Enrollment: 2100 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Xuanwu Hospital, Beijing (other)
• Locations: 1 site (Beijing, None Selected)
• Trial ID: NCT06610578 on ClinicalTrials.gov

What this trial studies

This observational study focuses on intracranial atherosclerosis stenosis (ICAS), a major cause of ischemic stroke, particularly in the Asian population. It aims to explore the effectiveness of fundus imaging as a non-invasive screening tool for early detection of ICAS, which could lead to timely interventions and improved patient outcomes. The study will include patients who have undergone recent imaging examinations like DSA, CTA, or MRA, and will assess their ability to cooperate with follow-up fundus examinations. By identifying patients at risk, the study seeks to enhance early warning and prevention strategies for stroke.

Who should consider this trial

Good fit: Ideal candidates are adults over 18 years old who have recently completed head and neck imaging examinations.

Not a fit: Patients with poor quality fundus images, intracranial mass lesions, severe organ diseases, or those who are pregnant or lactating may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved early detection and prevention of strokes in patients with intracranial atherosclerosis.

How similar studies have performed: While there are promising screening tools for ICAS, this specific approach using fundus imaging is relatively novel and has not been extensively tested.

Eligibility criteria

Inclusion Criteria:

1. The age is above 18 years old;
2. Complete head and neck DSA, CTA, MRA or HR-MRI examination within 2 weeks;
3. He/She can cooperate with follow-up fundus examination with free movement;
4. Signed informed consent.

Exclusion Criteria:

1. Poor quality of fundus images;
2. With intracranial mass lesions;
3. With severe heart, liver and kidney diseases;
4. With pregnancy and lactation.

Where this trial is running

Beijing, None Selected

• Xuanwu Hospital, Capital Medical University — Beijing, None Selected, China (RECRUITING)

Study contacts

• Study coordinator: Gao

Conditions: Intracranial Atherosclerosis, stroke, fundus imaging, intracranial atherosclerosis