Using Optical Coherence Tomography to Evaluate Intracranial Atherosclerosis
Official title: Optical Coherence Tomography for Intracranial Atherosclerotic Stenosis: a Prospective Registry Study (OCT-ICAS)
Run by Xuanwu Hospital, Beijing · NCT05550077 · Data updated 2026-11-12
This study is testing whether a special imaging technique can help doctors better understand and treat narrowing of brain arteries in patients at risk for strokes.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | Xuanwu Hospital, Beijing Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | March 15, 2020 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2027 |
| Registry record updated | September 23, 2022 |
| Trial ID | NCT05550077 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients with symptomatic ICAS who have experienced a transient ischemic attack or stroke and have a stenosis degree of 50% or greater.
✕Probably not a fit
Patients with arteriovenous malformations or aneurysms will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the clinical significance of optical coherence tomography (OCT) in the interventional treatment of intracranial atherosclerotic stenosis (ICAS). It aims to characterize the morphology and composition of atheromatous plaques in patients with ICAS, which may help predict stroke risk and guide therapeutic management. By utilizing OCT's high resolution, the study seeks to provide reliable information on vessel wall structure and correlate clinical data with plaque characteristics to identify potential biomarkers.
Why it matters
Potential benefit: If successful, this study could lead to improved risk assessment and management strategies for patients with intracranial atherosclerosis, potentially reducing the incidence of ischemic strokes.
How similar studies have gone: Other studies have shown promise in using advanced imaging techniques like OCT for vascular assessments, suggesting potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Symptomatic ICAS. Participants with ICAS with a transient ischaemic attack (TIA) or stroke attributable to the territory of the stenotic artery were defined as symptomatic. A TIA was defined as a transient episode of neurological dysfunction (focal weakness or language disturbance, transient monocular blindness, or required assistance in walking) caused by focal brain or retinal ischaemia that lasted for at least 10 minutes but resolved within 24 hours * Stenotic degree ≥ 50%, measured by digital subtraction angiography * The stenosis must located in at least one major intracranial artery (internal carotid artery, vertebral artery, middle cerebral artery, or basilar artery) Exclusion Criteria: * Arteriovenous Malformation * Aneurysm
Where it's running
-
Xuanwu Hospital, Capital Medical University
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Study coordinator: Liqun Jiao, Professor
- Email: liqunjiao@sina.cn
- Phone: +8613911224991
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.