Using Optical Coherence Tomography to Evaluate Intracranial Atherosclerosis
Optical Coherence Tomography for Intracranial Atherosclerotic Stenosis: a Prospective Registry Study (OCT-ICAS)
This study is testing whether a special imaging technique can help doctors better understand and treat narrowing of brain arteries in patients at risk for strokes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Xuanwu Hospital, Beijing Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT05550077 on ClinicalTrials.gov |
What this trial studies
This study evaluates the clinical significance of optical coherence tomography (OCT) in the interventional treatment of intracranial atherosclerotic stenosis (ICAS). It aims to characterize the morphology and composition of atheromatous plaques in patients with ICAS, which may help predict stroke risk and guide therapeutic management. By utilizing OCT's high resolution, the study seeks to provide reliable information on vessel wall structure and correlate clinical data with plaque characteristics to identify potential biomarkers.
Who should consider this trial
Good fit: Ideal candidates for this study are patients with symptomatic ICAS who have experienced a transient ischemic attack or stroke and have a stenosis degree of 50% or greater.
Not a fit: Patients with arteriovenous malformations or aneurysms will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved risk assessment and management strategies for patients with intracranial atherosclerosis, potentially reducing the incidence of ischemic strokes.
How similar studies have performed: Other studies have shown promise in using advanced imaging techniques like OCT for vascular assessments, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Symptomatic ICAS. Participants with ICAS with a transient ischaemic attack (TIA) or stroke attributable to the territory of the stenotic artery were defined as symptomatic. A TIA was defined as a transient episode of neurological dysfunction (focal weakness or language disturbance, transient monocular blindness, or required assistance in walking) caused by focal brain or retinal ischaemia that lasted for at least 10 minutes but resolved within 24 hours * Stenotic degree ≥ 50%, measured by digital subtraction angiography * The stenosis must located in at least one major intracranial artery (internal carotid artery, vertebral artery, middle cerebral artery, or basilar artery) Exclusion Criteria: * Arteriovenous Malformation * Aneurysm
Where this trial is running
Beijing, Beijing Municipality
- Xuanwu Hospital, Capital Medical University — Beijing, Beijing Municipality, China (Recruiting)
Study contacts
- Study coordinator: Liqun Jiao, Professor
- Email: liqunjiao@sina.cn
- Phone: +8613911224991
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.