Investigating how low shear stress affects blood vessel health in brain artery disease
Official title: Shear Stress and Endothelial Pathophysiology in Intracranial Atherosclerosis
Funded at University of California Los Angeles · NIH-11134234 · Data updated 2026-11-12
This study is looking at how low blood flow in the brain's arteries can lead to a condition called intracranial atherosclerosis, and it's for people who want to understand their risk of having another stroke; the researchers hope to find clues that could help create better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | February 1, 2020 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $608,059 |
| NIH project number | 2R01NS112799-06 |
| Project ID | NIH-11134234 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with intracranial atherosclerosis, particularly those at risk for recurrent strokes.
✕Less likely to help
Patients without a diagnosis of intracranial atherosclerosis or those who are not at risk for stroke may not benefit from this research.
What this research studies
This research focuses on understanding the role of low shear stress in the development of intracranial atherosclerosis, a condition affecting the arteries in the brain. By examining areas of low blood flow after arterial blockages, the study aims to identify markers that could predict recurrent strokes. The researchers will use advanced imaging techniques and flow models to analyze blood flow dynamics and endothelial cell behavior in affected arteries. This approach may lead to targeted therapies that could improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of strokes in patients with intracranial atherosclerosis.
How similar studies have gone: Previous research has shown promising results in understanding shear stress in systemic atherosclerosis, suggesting potential for success in this novel application to cerebral circulation.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Liebeskind, David Sigmund — University of California Los Angeles
- Study coordinator: Liebeskind, David Sigmund
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.