Using high-resolution MRI to study brain artery plaques in stroke patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients who have experienced ischemic stroke due to intracranial atherosclerosis, which is prevalent in Asia. It utilizes high-resolution magnetic resonance imaging (HRMRI) to non-invasively assess the characteristics of atherosclerotic plaques in the brain's arteries. By analyzing plaque composition and morphology, the study aims to enhance understanding of stroke etiology and inform secondary prevention strategies. The study will include patients aged 40 and older who have had a stroke within the last two weeks and meet specific inclusion criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\. Patient age ≥40 years
* 2\. Time of stroke onset: within 2 week
* 3\. Baseline NIHSS score ≤16
* 4\. Ischemic stroke confirmed by head CT or MRI
* 5\. Premorbid mRS ≤1
* 6\. The degree of stenosis of extracranial arteries including internal carotid artery, vertebral artery on the lesion side ≤50%
* 7\. The culprit plaque or possible culprit plaque with plaque burden of 40% or more found by HRMRI in the proximal part of the middle cerebral artery M1 segment or basilar artery of ipsilateral lesion
* 8\. Signed informed consent

Exclusion Criteria:

* 1\. Intracranial hemorrhage found by head CT
* 2\. Had a contraindication to MRI,or could not complete required MRI sequences
* 3\. Intracranial tumor, arteriovenous malformation, or aneurysm
* 4\. Comorbidity with any serious diseases and life expectancy is less than one year
* 5\. Pregnancy
* 6\. Patients not suitable for this clinical studies considered by researcher

Where it's running

• Department of Neurology, General Hospital of Northern Theater Command
  Shenyang, China Recruiting

Study contacts

• Principal investigator: HuiSheng Chen — General Hospital of Northern Theatre Command
• Study coordinator: HuiSheng

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.