Understanding skin-related side effects of cancer immunotherapy
Predictive modeling of cutaneous immune checkpoint inhibitor toxicities
This study is looking at skin problems that some cancer patients might experience while getting immune checkpoint inhibitors, with the goal of understanding how common these issues are and what might cause them, so we can help patients feel better and keep up with their important treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11045671 on NIH RePORTER |
What this research studies
This research investigates the skin-related toxicities that can occur in patients receiving immune checkpoint inhibitors (ICIs) for cancer treatment. It aims to identify the frequency and types of these skin reactions, known as cutaneous immune-related adverse events (cirAEs), and the factors that contribute to their development. By analyzing real-world data, the study seeks to improve patient outcomes by understanding how these side effects impact treatment and quality of life. The findings could help in developing strategies to mitigate these adverse effects and ensure patients can continue their life-saving cancer therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing treatment with immune checkpoint inhibitors for cancer who may experience skin-related side effects.
Not a fit: Patients not receiving immune checkpoint inhibitors or those without skin-related adverse events may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management of skin toxicities, allowing patients to receive effective cancer treatment without significant interruptions.
How similar studies have performed: Previous research has shown that understanding adverse effects of cancer therapies can lead to improved patient management, indicating potential success for this approach.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Semenov, Yevgeniy R — Massachusetts General Hospital
- Study coordinator: Semenov, Yevgeniy R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.