Clinical trial Recruiting at 1 site Interventional Women only

Examining LAG3 Expression in Triple Negative Breast Cancer

Official title: The Evaluation the Relationship Between LAG-3 Expression / Immune Checkpoint Protein Expression and Neoadjuvant Chemotherapy Plus Immune Checkpoint Inhibitor in Triple Negative Breast Cancer

Run by Samsung Medical Center · NCT06259162 · Data updated 2026-11-12

This study is testing how a protein called LAG-3 affects treatment outcomes in patients with triple negative breast cancer who are receiving chemotherapy along with an immune therapy.

Quick facts

Study typeInterventional
SexWomen only
Enrollment128 (estimated)
SponsorSamsung Medical Center
Academic / other
Drugs / interventionschemotherapy
Locations1 site (Seoul)
StatusRecruiting
StartedNovember 18, 2022
Main results expectedJuly 1, 2025
Study endsDecember 31, 2027
Registry record updatedFebruary 14, 2024
Trial IDNCT06259162 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals diagnosed with triple negative breast cancer who are scheduled to receive neoadjuvant chemotherapy.

Probably not a fit

Patients with HER2-positive or hormone receptor positive breast cancer will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the relationship between LAG-3 expression and immune checkpoint protein expression in patients with triple negative breast cancer undergoing neoadjuvant chemotherapy combined with an immune checkpoint inhibitor. The goal is to understand how these expressions may influence treatment outcomes. By analyzing tissue samples and patient responses, the study aims to provide insights into potential biomarkers for therapy effectiveness.

Why it matters

Potential benefit: If successful, this study could lead to improved treatment strategies for patients with triple negative breast cancer.

How similar studies have gone: While this approach is exploring a specific biomarker in a targeted population, similar studies have shown promise in utilizing immune checkpoint inhibitors in cancer treatment.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Planned neoadjuvant chemotherapy
* Triple negative breast cancer

Exclusion Criteria:

* HER2-positive breast cancer
* Hormone receptor positive breast cancer

Where it's running

  • Ji-Yeon Kim
    Seoul, South Korea
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.