Examining LAG3 Expression in Triple Negative Breast Cancer
Official title: The Evaluation the Relationship Between LAG-3 Expression / Immune Checkpoint Protein Expression and Neoadjuvant Chemotherapy Plus Immune Checkpoint Inhibitor in Triple Negative Breast Cancer
Run by Samsung Medical Center · NCT06259162 · Data updated 2026-11-12
This study is testing how a protein called LAG-3 affects treatment outcomes in patients with triple negative breast cancer who are receiving chemotherapy along with an immune therapy.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | Women only |
| Enrollment | 128 (estimated) |
| Sponsor | Samsung Medical Center Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Seoul) |
| Status | Recruiting |
| Started | November 18, 2022 |
| Main results expected | July 1, 2025 |
| Study ends | December 31, 2027 |
| Registry record updated | February 14, 2024 |
| Trial ID | NCT06259162 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals diagnosed with triple negative breast cancer who are scheduled to receive neoadjuvant chemotherapy.
✕Probably not a fit
Patients with HER2-positive or hormone receptor positive breast cancer will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the relationship between LAG-3 expression and immune checkpoint protein expression in patients with triple negative breast cancer undergoing neoadjuvant chemotherapy combined with an immune checkpoint inhibitor. The goal is to understand how these expressions may influence treatment outcomes. By analyzing tissue samples and patient responses, the study aims to provide insights into potential biomarkers for therapy effectiveness.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for patients with triple negative breast cancer.
How similar studies have gone: While this approach is exploring a specific biomarker in a targeted population, similar studies have shown promise in utilizing immune checkpoint inhibitors in cancer treatment.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Planned neoadjuvant chemotherapy * Triple negative breast cancer Exclusion Criteria: * HER2-positive breast cancer * Hormone receptor positive breast cancer
Where it's running
-
Ji-Yeon Kim
Seoul, South Korea Recruiting
Study contacts
- Study coordinator: Ji-Yeon Kim
- Email: jyeon25@skku.edu
- Phone: 82-2-3410-3459
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.