Understanding kidney issues caused by cancer immunotherapy
Rapid Diagnosis and Treatment Response Phenotyping of Immune Checkpoint Inhibitor-Associated Acute Interstitial Nephritis
['FUNDING_R01'] · YALE UNIVERSITY · NIH-10940754
This study is looking for a special marker in the blood that can help doctors understand and treat kidney problems caused by cancer medications, so they can better help patients who might not respond to regular treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10940754 on ClinicalTrials.gov |
What this research studies
This research focuses on patients who experience acute kidney injury due to immune checkpoint inhibitors used in cancer treatment. It aims to identify a specific biomarker, CXCL9, that can help diagnose this condition and predict how well patients will respond to corticosteroid treatment. By analyzing the biological pathways involved, the study seeks to improve treatment strategies for those who do not respond to standard therapies. The research will involve recruiting 400 participants from multiple healthcare systems who are undergoing treatment with immune checkpoint inhibitors.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients receiving immune checkpoint inhibitor therapy who develop acute kidney injury.
Not a fit: Patients who are not undergoing immune checkpoint inhibitor therapy or who do not develop acute kidney injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to faster and more accurate diagnosis and treatment for patients experiencing kidney problems related to cancer immunotherapy.
How similar studies have performed: Previous research has shown promise in identifying biomarkers for immune-related adverse events, suggesting that this approach may yield valuable insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOLEDINA, DENNIS G. — YALE UNIVERSITY
- Study coordinator: MOLEDINA, DENNIS G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.