Parathyroid cell transplantation to treat hypoparathyroidism
Official title: Parathyroid Allotransplant for Treatment of Hypoparathyroidism
Funded at University of California, San Francisco · NIH-11386649 · Data updated 2026-11-12
A doctor-scientist team at a major university plans a parathyroid cell transplant to help people with chronic hypoparathyroidism reduce dependence on calcium and vitamin D supplements.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | August 15, 2025 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $312,000 |
| NIH project number | 5R01DK141970-02 |
| Project ID | NIH-11386649 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with chronic hypoparathyroidism who require ongoing calcium/vitamin D therapy and are candidates for parathyroid grafting.
✕Less likely to help
Patients with contraindications to transplantation or those not eligible for grafting may not benefit from this approach.
What this research studies
This project aims to replace missing PTH by transplanting parathyroid cells to restore normal calcium and phosphorus balance. It will compare autograft transplantation, where a patient’s own tissue is used, with allo-transplant approaches to provide hormone production. The study will monitor calcium levels, kidney stone risk, and potential tissue calcifications, while aiming to minimize adverse events related to transplantation. Participants would be selected based on hypoPT severity and previous treatment responses, with careful follow-up to manage immune considerations if allografts are used.
Why it matters
Potential benefit: If successful, patients could achieve better calcium control and fewer symptoms, reducing the need for high-dose calcium and vitamin D supplementation.
How similar studies have gone: Parathyroid autotransplantation has been used for decades and shows potential for autoregulation; allotransplant approaches are being explored with cautious optimization.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Stock, Peter G — University of California, San Francisco
- Study coordinator: Stock, Peter G
Related research
Other NIH-funded projects on the same topics.
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Long-acting parathyroid hormone treatment for hypoparathyroidism
A long-lasting parathyroid hormone medicine designed to help people with hypoparathyroidism keep their calcium levels steady and take fewer pills.
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Understanding hypoparathyroidism effects on calcium and organ health
This project follows people with hypoparathyroidism to learn how low parathyroid hormone and calcium levels affect organs and overall health over time.
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Understanding the effects of hypoparathyroidism on health outcomes.
This study is looking at hypoparathyroidism, a rare condition that causes low hormone and calcium levels, to better understand how it affects health and leads to problems like kidney issues and heart complications, so we can improve how it's diagnosed and treated for those living with it.
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A new treatment for low parathyroid hormone levels in patients with hypoparathyroidism
This study is testing a new way to deliver parathyroid hormone continuously for people with hypoparathyroidism, aiming to help balance calcium and phosphorus levels in the body and make life easier compared to taking multiple daily supplements.
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German Hypoparathyroidism Registry
This registry in Germany collects information from adults with chronic hypoparathyroidism or pseudohypoparathyroidism to better understand how the condition affects people over time and to support future research.
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Encaleret for Chronic Hypoparathyroidism: Testing if it helps symptoms and safety
This study tests whether taking encaleret pills can help people with chronic hypoparathyroidism, while being safe and tolerable.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.