Understanding hypoparathyroidism effects on calcium and organ health
Advancing Product Development for Hypoparathyroidism: A Prospective Natural History Study of the Clinical Outcomes and Regulation of Disordered Mineral Metabolism
This project follows people with hypoparathyroidism to learn how low parathyroid hormone and calcium levels affect organs and overall health over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11145038 on NIH RePORTER |
What this research studies
If you join, you will be followed over time so researchers can track symptoms, medications, and health events related to hypoparathyroidism. Regular blood and urine tests will measure calcium, phosphate, PTH, and other markers of mineral metabolism. Imaging and kidney tests may be done to look for calcium deposits in the brain, blood vessels, kidneys, and other organs. The team will combine these clinical, laboratory, and imaging data to map who develops complications and why, with the goal of guiding better care.
Who could benefit from this research
Good fit: People with a diagnosis of chronic hypoparathyroidism, including those taking calcium, active vitamin D, or PTH therapy, who can attend follow-up visits and testing are the best candidates.
Not a fit: People without chronic hypoparathyroidism (for example, transient postoperative low calcium) or those unable to attend follow-up visits or testing are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, this work could help detect and prevent organ calcifications and other long-term complications of hypoparathyroidism and inform better treatment approaches.
How similar studies have performed: Prior registries and observational studies have reported vascular and brain calcifications in hypoparathyroidism, but this larger prospective natural history approach is relatively new and aims to fill key knowledge gaps.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Rubin, Mishaela R — Columbia University Health Sciences
- Study coordinator: Rubin, Mishaela R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.