Understanding hypoparathyroidism effects on calcium and organ health
Official title: Advancing Product Development for Hypoparathyroidism: A Prospective Natural History Study of the Clinical Outcomes and Regulation of Disordered Mineral Metabolism
Funded at Columbia University Health Sciences · NIH-11145038 · Data updated 2026-11-12
This project follows people with hypoparathyroidism to learn how low parathyroid hormone and calcium levels affect organs and overall health over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 15, 2022 |
| Project end | August 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $399,999 |
| NIH project number | 5R01FD007629-04 |
| Project ID | NIH-11145038 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with a diagnosis of chronic hypoparathyroidism, including those taking calcium, active vitamin D, or PTH therapy, who can attend follow-up visits and testing are the best candidates.
✕Less likely to help
People without chronic hypoparathyroidism (for example, transient postoperative low calcium) or those unable to attend follow-up visits or testing are unlikely to benefit from participation.
What this research studies
If you join, you will be followed over time so researchers can track symptoms, medications, and health events related to hypoparathyroidism. Regular blood and urine tests will measure calcium, phosphate, PTH, and other markers of mineral metabolism. Imaging and kidney tests may be done to look for calcium deposits in the brain, blood vessels, kidneys, and other organs. The team will combine these clinical, laboratory, and imaging data to map who develops complications and why, with the goal of guiding better care.
Why it matters
Potential benefit: If successful, this work could help detect and prevent organ calcifications and other long-term complications of hypoparathyroidism and inform better treatment approaches.
How similar studies have gone: Prior registries and observational studies have reported vascular and brain calcifications in hypoparathyroidism, but this larger prospective natural history approach is relatively new and aims to fill key knowledge gaps.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Rubin, Mishaela R — Columbia University Health Sciences
- Study coordinator: Rubin, Mishaela R
Related research
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Parathyroid cell transplantation to treat hypoparathyroidism
A doctor-scientist team at a major university plans a parathyroid cell transplant to help people with chronic hypoparathyroidism reduce dependence on calcium and vitamin D supplements.
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Long-acting parathyroid hormone treatment for hypoparathyroidism
A long-lasting parathyroid hormone medicine designed to help people with hypoparathyroidism keep their calcium levels steady and take fewer pills.
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Understanding the effects of hypoparathyroidism on health outcomes.
This study is looking at hypoparathyroidism, a rare condition that causes low hormone and calcium levels, to better understand how it affects health and leads to problems like kidney issues and heart complications, so we can improve how it's diagnosed and treated for those living with it.
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A new treatment for low parathyroid hormone levels in patients with hypoparathyroidism
This study is testing a new way to deliver parathyroid hormone continuously for people with hypoparathyroidism, aiming to help balance calcium and phosphorus levels in the body and make life easier compared to taking multiple daily supplements.
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German Hypoparathyroidism Registry
This registry in Germany collects information from adults with chronic hypoparathyroidism or pseudohypoparathyroidism to better understand how the condition affects people over time and to support future research.
-
Encaleret for Chronic Hypoparathyroidism: Testing if it helps symptoms and safety
This study tests whether taking encaleret pills can help people with chronic hypoparathyroidism, while being safe and tolerable.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.