Understanding the effects of hypoparathyroidism on health outcomes.
Official title: Advancing Product Development for Hypoparathyroidism: A Prospective Natural History Study of the Clinical Outcomes and Regulation of Disordered Mineral Metabolism
Funded at Columbia University Health Sciences · NIH-10891413 · Data updated 2026-11-12
This study is looking at hypoparathyroidism, a rare condition that causes low hormone and calcium levels, to better understand how it affects health and leads to problems like kidney issues and heart complications, so we can improve how it's diagnosed and treated for those living with it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 15, 2022 |
| Project end | August 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $399,887 |
| NIH project number | 5R01FD007629-03 |
| Project ID | NIH-10891413 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with hypoparathyroidism who experience related health complications.
✕Less likely to help
Patients without a diagnosis of hypoparathyroidism or those who do not experience complications related to the condition may not benefit from this research.
What this research studies
This research investigates hypoparathyroidism, a rare condition where patients have low levels of parathyroid hormone and calcium, leading to serious health issues like seizures and heart problems. The study aims to explore the natural history of this condition and its complications, including kidney disease and vascular calcifications. By collecting data from patients, the research seeks to identify the links between hypoparathyroidism and these complications, ultimately aiming to improve diagnosis and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to better management and treatment options for patients with hypoparathyroidism, reducing their risk of serious complications.
How similar studies have gone: While there have been studies on hypoparathyroidism, this research aims to fill significant gaps in understanding the condition's natural history and its complications, making it a novel approach.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Rubin, Mishaela R — Columbia University Health Sciences
- Study coordinator: Rubin, Mishaela R
Related research
Other NIH-funded projects on the same topics.
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Parathyroid cell transplantation to treat hypoparathyroidism
A doctor-scientist team at a major university plans a parathyroid cell transplant to help people with chronic hypoparathyroidism reduce dependence on calcium and vitamin D supplements.
-
Long-acting parathyroid hormone treatment for hypoparathyroidism
A long-lasting parathyroid hormone medicine designed to help people with hypoparathyroidism keep their calcium levels steady and take fewer pills.
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Understanding hypoparathyroidism effects on calcium and organ health
This project follows people with hypoparathyroidism to learn how low parathyroid hormone and calcium levels affect organs and overall health over time.
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A new treatment for low parathyroid hormone levels in patients with hypoparathyroidism
This study is testing a new way to deliver parathyroid hormone continuously for people with hypoparathyroidism, aiming to help balance calcium and phosphorus levels in the body and make life easier compared to taking multiple daily supplements.
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German Hypoparathyroidism Registry
This registry in Germany collects information from adults with chronic hypoparathyroidism or pseudohypoparathyroidism to better understand how the condition affects people over time and to support future research.
-
Encaleret for Chronic Hypoparathyroidism: Testing if it helps symptoms and safety
This study tests whether taking encaleret pills can help people with chronic hypoparathyroidism, while being safe and tolerable.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.