A new treatment for low parathyroid hormone levels in patients with hypoparathyroidism
Long-acting PTH for hypoparathyroidism
This study is testing a new way to deliver parathyroid hormone continuously for people with hypoparathyroidism, aiming to help balance calcium and phosphorus levels in the body and make life easier compared to taking multiple daily supplements.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Extend Biosciences, INC. NIH-funded |
| Lab location | 1 site (Newton, UNITED STATES) |
| Project ID | NIH-10822753 on NIH RePORTER |
What this research studies
This research investigates a long-acting formulation of parathyroid hormone (PTH) for patients suffering from hypoparathyroidism, a condition characterized by insufficient PTH production. The approach involves continuous infusion of PTH to mimic natural hormone levels, potentially restoring normal calcium and phosphorus levels in the body. Current treatments often require multiple daily supplements of calcium and vitamin D, which do not address the root cause of the hormone deficiency. By using a pump to deliver PTH continuously, the study aims to improve patient outcomes and reduce the complications associated with traditional therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with hypoparathyroidism who struggle with managing their condition through current supplementation methods.
Not a fit: Patients who do not have hypoparathyroidism or those whose condition is adequately managed with existing treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the management of hypoparathyroidism, reducing the need for multiple supplements and minimizing related health complications.
How similar studies have performed: Previous clinical trials have shown promising results with continuous infusion of PTH, indicating that this approach may be effective in managing hypoparathyroidism.
Where this research is happening
Newton, UNITED STATES
- Extend Biosciences, INC. — Newton, United States (Active)
Researchers
- Principal investigator: Hales, Laura M — Extend Biosciences, INC.
- Study coordinator: Hales, Laura M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.