Condition

Hypogonadism clinical trials and research

• 11Clinical trials
• 8NIH research projects
• 5Countries

Newest Hypogonadism clinical trials

All recruiting trials (11)

• Men's experiences with ICSI and low sperm quality

  This project will see if Danish men with low sperm quality who undergo ICSI have lower quality of life or low testosterone and how they experience interactions with health professionals.

  Recruiting Regionshospitalet Viborg, Skive · Skive, Midt Jylland · NCT07546435

• Tamoxifen to speed testosterone recovery after ADT in men with prostate cancer

  Tamoxifen is being tested to see if it helps men who have been on androgen deprivation therapy regain normal testosterone faster after treatment.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT07535905

• Comparing oral and transdermal estrogen therapy in women with Turner syndrome

  This study is testing whether taking estrogen as a pill or through the skin is better for women with Turner syndrome in terms of their overall health and well-being.

  Recruiting Phase 4 University of Aarhus · Aarhus, Aarhus N · NCT06570460

• Comparing oral and transdermal estrogen treatment in women with Turner syndrome

  This study is testing whether taking estrogen by mouth or through the skin works better for women with Turner syndrome.

  Recruiting Phase 4 University of Aarhus · Aarhus, Aarhus N · NCT06544473

• Hormonal intervention to prevent injuries in military personnel during training

  This study is testing whether hormone therapy can help military personnel train better and avoid injuries during tough training sessions.

  Recruiting Phase 4 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06455969

• Observing how the environment affects reproductive health

  This study looks at how different environmental factors might affect reproductive health in people aged 8 and older, including issues like infertility and hormone problems.

  Recruiting National Institutes of Health Clinical Center (CC) · Research Triangle Park, North Carolina · NCT06280807

• Examining the effects of sex steroid replacement therapy in transgender military personnel with hypogonadism

  This study tests how hormone therapy affects the health and well-being of active-duty military personnel with low testosterone and gender identity issues.

  Recruiting Walter Reed National Military Medical Center · Bethesda, Maryland · NCT06247267

• Effect of testosterone therapy on outcomes after prostate surgery

  This study is testing if testosterone therapy can help men with low testosterone feel better and improve their quality of life after prostate cancer surgery.

  Recruiting at 10 sites Phase 3 Canisius-Wilhelmina Hospital · Amsterdam and 9 other locations · NCT04833426

• Investigating the link between HIV infection and male hypogonadism

  This study looks at how common low testosterone is in men with HIV compared to men without HIV to see what factors might be linked to it.

  Recruiting National Taiwan University Hospital · Taipei · NCT04760574

• Combining testosterone therapy with walking training to improve health after spinal cord injury

  This study is testing if combining testosterone therapy with walking training can help men with spinal cord injuries who have low testosterone and trouble walking improve their health and mobility.

  Recruiting at 2 sites Phase 2 North Florida Foundation for Research and Education · Gainesville, Florida and 1 other locations · NCT04460872

• Understanding inherited reproductive disorders

  This study looks at how certain reproductive disorders, like delayed or early puberty, might run in families by testing blood samples and gathering information from people who have these issues.

  Recruiting at 2 sites National Institutes of Health Clinical Center (CC) · Bethesda, Maryland and 1 other locations · NCT01500447

NIH-funded research (8)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How the gene regulator Gli3 influences Kallmann syndrome and normosmic hypogonadotropic hypogonadism

  Researchers are looking at whether changes in the gene regulator Gli3 help explain why some adults develop Kallmann syndrome or normosmic idiopathic hypogonadotropic hypogonadism.

  NIH research State University of New York at Albany · Albany, United States · NIH-11321670

• Insulin problems in brain support cells linked to delayed puberty and low reproductive hormones

  This work looks at whether insulin resistance in brain support cells called astrocytes leads to delayed puberty and low reproductive hormones that can cause infertility.

  NIH research University of Toledo Health Sci Campus · Toledo, United States · NIH-11261775

• Exploring how a specific protein affects puberty and fertility in certain genetic conditions

  This study is looking at how a specific protein called Gli3 affects Kallmann syndrome and a related condition that can cause delayed puberty and infertility, with the goal of understanding how important brain cells develop and move during pregnancy, which could help find better treatments for these issues.

  NIH research State University of New York at Albany · Albany, United States · NIH-11143167

• How insulin resistance in brain cells affects puberty and reproductive health

  This study is looking at how certain brain cells called astrocytes help control reproductive hormones and puberty, especially how insulin affects them, to better understand why some people might experience delays in puberty or fertility issues.

  NIH research University of Toledo Health Sci Campus · Toledo, United States · NIH-11012836

• The effects of testosterone therapy on bone health in men with diabetes and low testosterone levels

  This study is looking at how testosterone therapy might help improve bone health in men who have diabetes and low testosterone levels, so if you're dealing with these issues, this research could offer some helpful insights into your treatment options.

  NIH research Michael E Debakey VA Medical Center · Houston, United States · NIH-10977050

• Pulsatile kisspeptin (Kp-10) to boost reproductive hormones in hypogonadotropic hypogonadism

  This project gives pulses of the natural brain signal kisspeptin (Kp-10) to people with hypogonadotropic hypogonadism to try to restore reproductive hormones and function.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10930895

• Testosterone Replacement to Reduce Pain for Men with Opioid-Related Low Testosterone

  This project tests whether giving physiologic testosterone helps reduce pain for men who are on opioid medications and have low testosterone.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10904002

• Using testosterone to help men with pain caused by opioid treatment

  This study is looking at how testosterone replacement therapy might help men who have low testosterone levels due to long-term opioid use, with the goal of reducing their pain and improving their overall quality of life.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10692766

Related topics

Quick answers

How many Hypogonadism clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (5 trials), Denmark (3 trials), Taiwan (1 trial), Canada (1 trial), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Phase 2: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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