Examining the effects of sex steroid replacement therapy in transgender military personnel with hypogonadism
Official title: The Effect on Sex Steroid Replacement Therapy in the Hypogonadism and Transgender Active-Duty Population on Bone Density, Fractures, Memory/Cognitive Function and Qualities of Life
Run by Walter Reed National Military Medical Center · NCT06247267 · Data updated 2026-11-12
This study tests how hormone therapy affects the health and well-being of active-duty military personnel with low testosterone and gender identity issues.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 75 (estimated) |
| Sponsor | Walter Reed National Military Medical Center Federal |
| Locations | 1 site (Bethesda, Maryland) |
| Status | Recruiting |
| Started | March 9, 2021 |
| Main results expected | August 2025 |
| Study ends | August 2025 |
| Registry record updated | July 29, 2025 |
| Trial ID | NCT06247267 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include male and female Department of Defense healthcare beneficiaries aged 18-65 who have been diagnosed with primary hypogonadism or are undergoing transgender treatment for at least six months.
✕Probably not a fit
Patients who are pregnant, have significant cardiac or renal issues, or are scheduled for deployment may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the impact of sex steroid replacement therapy on active-duty military personnel diagnosed with hypogonadism and gender identity dysphoria. It focuses on individuals receiving testosterone or estrogen therapy to assess physiological changes and health outcomes associated with these treatments. Participants must be stable on their hormonal therapy for at least six months and will be monitored for various health indicators related to bone density and mental health. The study aims to gather data to better understand the needs of this growing patient population within the military healthcare system.
Why it matters
Potential benefit: If successful, this study could improve the management of hypogonadism and gender identity dysphoria in military personnel, leading to better health outcomes and quality of life.
How similar studies have gone: While there is limited data on large-scale studies, some smaller studies have indicated potential benefits of sex steroid replacement therapy in similar populations, suggesting a promising avenue for further exploration.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male and female DoD health care beneficiaries * Ages 18-65 * Diagnosed with primary hypogonadism or transgender treatment for at least 6 months * Under care for gender identity dysphoria * On stable dose of sex steroid hormonal therapy for at least 6 months prior to enrolling * Must be living in the Washington, D.C. area for at least 12 months following enrollment Exclusion Criteria: * Pregnancy, plan for pregnancy in the next 12 months * Cardiac disease, especially coronary artery disease * Malabsorption disorder * Gastrointestinal surgeries * Significant renal or liver dysfunction * Seizure disorders * recent orders to move out of the geographic area * Age less than 18 years old or older than 65 years old * Scheduled for deployment
Where it's running
-
Walter Reed National Military Medical Center
Bethesda, Maryland, United States Recruiting
Study contacts
- Principal investigator: Thanh D Hoang, MD — Walter Reed National Military Medical Center
- Study coordinator: CAPT Than D Hoang, D.O., MC, USN
- Email: thanh.d.hoang.mil@health.mil
- Phone: 301-295-5165
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.