Using testosterone to help men with pain caused by opioid treatment
Androgen Replacement to Improve Patient-Important Outcomes in Men with Opioid-Induced Hypogonadism
This study is looking at how testosterone replacement therapy might help men who have low testosterone levels due to long-term opioid use, with the goal of reducing their pain and improving their overall quality of life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10692766 on NIH RePORTER |
What this research studies
This research investigates how testosterone replacement therapy can alleviate pain and improve quality of life in men suffering from opioid-induced hypogonadism. Many men on chronic opioid medications experience a drop in testosterone levels, which can worsen their pain and overall well-being. The study aims to assess the effectiveness of testosterone in reducing pain perception and enhancing life quality through well-designed clinical trials. Participants will be monitored for changes in pain levels and quality of life indicators.
Who could benefit from this research
Good fit: Ideal candidates for this research are men who are experiencing chronic pain and have low testosterone levels due to opioid treatment.
Not a fit: Patients who are not on opioid medications or who have normal testosterone levels may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new treatment option for men suffering from chronic pain due to opioid use, potentially reducing their reliance on pain medications.
How similar studies have performed: Preliminary trials have shown promise in using testosterone replacement for improving pain and quality of life in similar patient populations, but larger, adequately-powered trials are needed.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Basaria, Shehzad — Brigham and Women's Hospital
- Study coordinator: Basaria, Shehzad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.