Exploring how a specific protein affects puberty and fertility in certain genetic conditions
Official title: Understanding the role of the transcription factor Gli3 in Kallmann syndrome and normosmic forms of idiopathic hypogonadotropic hypogonadism
Funded at State University of New York at Albany · NIH-11143167 · Data updated 2026-11-12
This study is looking at how a specific protein called Gli3 affects Kallmann syndrome and a related condition that can cause delayed puberty and infertility, with the goal of understanding how important brain cells develop and move during pregnancy, which could help find better treatments for these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Albany NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | March 12, 2019 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $328,071 |
| NIH project number | 5R01HD097331-07 |
| Project ID | NIH-11143167 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Kallmann syndrome or normosmic idiopathic hypogonadotropic hypogonadism.
✕Less likely to help
Patients who do not have Kallmann syndrome or normosmic idiopathic hypogonadotropic hypogonadism may not benefit from this research.
What this research studies
This research investigates the role of the Gli3 transcription factor in Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism, conditions that can lead to delayed puberty and infertility. The study focuses on understanding how neurons that produce gonadotropin-releasing hormone develop and migrate during embryonic growth, which is crucial for normal sexual maturation. By examining human patients, the research aims to uncover the cellular and molecular mechanisms that contribute to these conditions, potentially leading to new insights into treatment options.
Why it matters
Potential benefit: If successful, this research could provide new understanding and potential treatments for individuals experiencing delayed puberty and infertility due to these genetic conditions.
How similar studies have gone: While the specific focus on Gli3 in these conditions may be novel, previous research has successfully identified genetic factors involved in similar developmental processes.
Where this research is happening
-
State University of New York at Albany
Albany, United States Active
Researchers
- Principal investigator: Forni, Paolo E — State University of New York at Albany
- Study coordinator: Forni, Paolo E
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How the gene regulator Gli3 influences Kallmann syndrome and normosmic hypogonadotropic hypogonadism
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.