Comparing oral and transdermal estrogen therapy in women with Turner syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase IV, randomized controlled crossover trial investigates the long-term effects of oral versus transdermal estrogen replacement therapy (ERT) in women with Turner syndrome. The study involves 50 participants with Turner syndrome aged 18-50, who will undergo a wash-out period before being randomized to receive either oral or transdermal ERT for six months, followed by a crossover to the alternate treatment for another six months. The trial aims to clarify various health risks associated with Turner syndrome and evaluate the efficacy of both ERT routes on endocrine, metabolic, cardiovascular, and thromboembolic factors.

Why it matters

Who can join: the full rules

Inclusion criteria:

For participants with TS:

* Diagnosis of TS regardless of karyotype
* Age 18-50 years
* Already receiving estrogen treatment

For healthy controls:

* Female
* Age 18-50 years
* Previously healthy
* Not receiving any medication
* Not using any form of contraceptive pills
* No mental or psychiatric disorders

Exclusion criteria:

* Active systemic chronic diseases
* Known or suspected breast cancer
* Known or suspected estradiol-dependent tumors (endometrial cancer or similar)
* Untreated endometrial hyperplasia
* Current or previous venous thromboembolism
* Acute or previous liver disease where liver enzymes are still elevated by a factor 3 or more
* Known hypersensitivity to the medications used
* Pregnancy
* Menopause (for the control group only)

Where it's running

• Department of Endocrinology and Internal Medicine, Aarhus University Hospital
  Aarhus, Aarhus N, Denmark Recruiting

Study contacts

• Principal investigator: Claus H Gravholt, Professor — Aarhus University Hospital
• Study coordinator: Camilla M Balle, Ph.d.-student
• Email: camibl@clin.au.dk
• Phone: 40769623

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Comparing oral and transdermal estrogen treatment in women with Turner syndrome

  This study is testing whether taking estrogen by mouth or through the skin works better for women with Turner syndrome.

  Recruiting Phase 4 University of Aarhus · Aarhus, Aarhus N · NCT06544473

• Investigating the link between HIV infection and male hypogonadism

  This study looks at how common low testosterone is in men with HIV compared to men without HIV to see what factors might be linked to it.

  Recruiting National Taiwan University Hospital · Taipei · NCT04760574

• SI-B036 safety test in advanced and metastatic solid tumors

  This early-phase study checks whether SI-B036 is safe and tolerable in adults with advanced or metastatic solid cancers who have had prior therapy.

  Recruiting at 4 sites Phase 1 SystImmune Inc. · New Haven, Connecticut and 6 other locations · NCT07857616

• Inpegsomatropin vs Givopegsomatropin for short stature in girls with Turner syndrome

  A 52-week, multicenter, randomized study tests whether Inpegsomatropin injections help prepubertal girls with Turner syndrome grow taller compared with a known treatment.

  Recruiting at 49 sites Phase 3 Xiamen Amoytop Biotech Co., Ltd. · Anyang and 50 other locations · NCT07614152

• Adherence to a creatine-based nutritional supplement in estrogen-depleted women

  This 12-week observational project will test how well estrogen-depleted women stick to taking a creatine-based nutritional supplement.

  Recruiting at 3 sites Margan Biotech · Madrid, Madrid and 3 other locations · NCT07580846

• Men's experiences with ICSI and low sperm quality

  This project will see if Danish men with low sperm quality who undergo ICSI have lower quality of life or low testosterone and how they experience interactions with health professionals.

  Recruiting Regionshospitalet Viborg, Skive · Skive, Midt Jylland · NCT07546435

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.