Comparing oral and transdermal estrogen treatment in women with Turner syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase IV randomized crossover trial evaluates the effects of oral versus transdermal estrogen replacement therapy in women with Turner syndrome. Over a 5-week period, 50 participants aged 18-50 will receive each treatment for 14 days, separated by a one-week washout. The study aims to determine the dose equivalence of the two estradiol regimens by measuring various estradiol-dependent markers. Blood tests will be conducted at multiple points to assess the impact of each treatment method.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of TS regardless of karyotype
* Age 18-50 years
* Already receiving estrogen treatment

Exclusion Criteria:

* Active systemic chronic diseases
* Known or suspected breast cancer
* Known or suspected estradiol-dependent tumors (endometrial cancer or similar)
* Untreated endometrial hyperplasia
* Current or previous venous thromboembolism
* Acute or previous liver disease where liver enzymes are still elevated by a factor 3 or more
* Known hypersensitivity to the medications used
* Pregnancy

Where it's running

• Department of Endocrinology and Internal Medicine, Aarhus University Hospital
  Aarhus, Aarhus N, Denmark Recruiting

Study contacts

• Principal investigator: Claus H Gravholt, Professor — Aarhus University Hospital
• Study coordinator: Camilla M Balle, Ph.d.-student
• Email: camibl@clin.au.dk
• Phone: 40769623

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.