Examining the link between gut bacteria, isoflavones, and cholesterol levels

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the relationship between serum and fecal isoflavones, the abundance of TMA-producing bacteria, and serum TMAO levels in individuals with hyperlipidemia and healthy subjects. It aims to explore how dietary isoflavones may influence gut microbiota and subsequently affect cardiovascular disease risk. By analyzing the gut microbiome's role in metabolizing isoflavones, the study seeks to provide insights into dietary interventions for managing cholesterol levels and cardiovascular health.

Why it matters

Who can join: the full rules

* Inclusion Criteria:
* Hyperlipidemia inclusion criteria:
* 18-70 years old；
* patients diagnosed with hyperlipidemia；
* Healthy people inclusion criteria:
* 18-70 years old；
* male weight ≥50.0kg, female weight ≥45.0kg; body mass index (BMI) within the range of 19.0-26.0 kg/m2 (including critical values);
* volunteers have no history of chronic diseases or serious diseases such as cardiovascular, liver, kidney, respiratory, blood and lymphatic, endocrine, immune, mental, neuromuscular, gastrointestinal system within three years, and are in good overall health.
* Exclusion Criteria:
* Consuming dietary supplements (ω-3 fatty acids, probiotics, prebiotics, plant stanols/sterols) 1 month before the study;
* Using antibiotics, antidiarrheal drugs, statins, fibrates and other drugs within 2 months before the study;
* Drinking alcohol (\> 2 cups per day);
* Hyperlipidemia patients with inflammatory bowel disease or irritable bowel syndrome and healthy people.

Where it's running

• Zhujiang Hospital of Southern Medical University
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Study coordinator: Waijiao Tang, PhD
• Email: tangwaijiao_2006@126.com
• Phone: +8615521281466

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Enlicitide (MK-0616) for adults with high cholesterol in India

  This study tests whether enlicitide helps lower bad cholesterol (LDL-C) compared with placebo in adults with hyperlipidemia/hypercholesterolemia.

  Recruiting at 2 sites Phase 3 Merck Sharp & Dohme LLC · Belagavi, Karnataka and 1 other locations · NCT07821944

• HRS-7249 extension study for people with high triglycerides

  This extension study tests whether repeat injections of HRS-7249 are safe and keep triglyceride levels low in adults who previously completed the parent study or have high fasting triglycerides.

  Recruiting at 2 sites Phase 2 Fujian Shengdi Pharmaceutical Co., Ltd. · Jinan, Shandong and 1 other locations · NCT07799688

• Bacillus subtilis and Enterococcus faecium Probiotic Plus Lipid-Lowering Therapy for HTG-AP

  This trial tests whether adding a probiotic capsule to standard lipid-lowering therapy helps people with mild HTG-AP see lower triglycerides and better recovery.

  Recruiting Phase 4 Zhongshan Hospital Xiamen University · Xiamen, Fujian · NCT07720232

• EHR-guided LDL cholesterol optimization after a heart event

  A pharmacist-guided program using electronic health records to help adults in Alberta reach LDL goals after a heart event by adjusting medications and ordering tests.

  Recruiting at 2 sites University of Alberta · Edmonton, Alberta and 1 other locations · NCT07685639

• Spermidine supplement for lipid and weight changes in adults with obesity and high cholesterol

  This study tests whether taking spermidine daily for 1 month can improve blood lipids and body weight in adults who are overweight or obese with high cholesterol, while monitoring safety.

  Recruiting Shanghai 10th People's Hospital · Shanghai, Shanghai Municipality · NCT07662330

• Digital health platform to help prevent and manage high blood pressure, lipids, and kidney and heart disease

  This trial tests a mobile digital health platform to help people with hypertension, dyslipidemia, and related conditions in New Taipei City see if the platform improves blood pressure, cholesterol, and kidney health.

  Recruiting New Taipei City Medical Association · New Taipei City · NCT07588256

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.