IL-19's role in improving lymphatic function during high cholesterol levels
Official title: IL-19 Modifies Lymphatic Flux During Hyperlipidemia
Funded at Temple Univ of the Commonwealth · NIH-10825817 · Data updated 2026-11-12
This study is looking at how a protein called IL-19 influences the lymphatic system and inflammation related to heart disease, with the hope that improving lymphatic function could help reduce harmful plaque in arteries, which might lead to new treatments for better heart health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 16, 2024 |
| Project end | September 15, 2028 |
| Funding year | 2024 |
| Award (this year) | $34,803 |
| NIH project number | 1F30HL172580-01 |
| Project ID | NIH-10825817 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for cardiovascular diseases, particularly those with high cholesterol or atherosclerosis.
✕Less likely to help
Patients with non-cardiovascular related conditions or those not experiencing issues related to cholesterol or atherosclerosis may not benefit from this research.
What this research studies
This research investigates how IL-19, a cytokine, affects lymphatic function and inflammation in the context of atherosclerosis, a major cardiovascular disease. By exploring the relationship between lymphatic vessels and cholesterol transport, the study aims to understand how enhancing lymphatic function could help reduce plaque buildup in arteries. Patients may benefit from insights into new therapeutic approaches that target inflammation and lymphatic health to improve cardiovascular outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce atherosclerosis and improve heart health.
How similar studies have gone: Previous research has shown promising results in targeting inflammation and lymphatic function in cardiovascular diseases, suggesting potential for success in this approach.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Peluzzo, Amanda — Temple Univ of the Commonwealth
- Study coordinator: Peluzzo, Amanda
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.