NIH-funded research NIH-funded research

Improving cholesterol management for patients in the emergency department

Official title: Initiating Preventive Care for Hyperlipidemia in the Emergency Department: The EMERALD Trial

Funded at Wake Forest University Health Sciences · NIH-11056835 · Data updated 2026-11-12

This study is looking at a new way to help people with high cholesterol who come to the emergency room for chest pain, by giving them special treatment during their visit to see if it helps lower their cholesterol better than the usual care.

More Hyperlipidemia research and trials

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionWake Forest University Health Sciences
NIH-funded
Lab location1 site (Winston-Salem, United States)
Project startApril 1, 2024
Project endMarch 31, 2029
Funding year2025
Award (this year)$155,993
NIH project number5K23HL169929-02
Project IDNIH-11056835 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are patients visiting the emergency department with chest pain who may have undiagnosed or unmanaged high cholesterol.

Less likely to help

Patients who do not present with chest pain or have already been diagnosed and are effectively managing their hyperlipidemia may not benefit from this research.

What this research studies

This research investigates a new approach to managing high cholesterol in patients who visit the emergency department (ED) for chest pain. It aims to implement a preventive care intervention called EMERALD, which will provide patients with effective treatments for hyperlipidemia during their ED visit. By conducting a randomized trial, the research will compare the outcomes of patients receiving this intervention against those receiving standard care, focusing on cholesterol reduction and patient adherence to treatment. The study seeks to address the gap in preventive cardiovascular care that often occurs in acute care settings.

Why it matters

Potential benefit: If successful, this research could lead to better cholesterol management and reduced risk of cardiovascular diseases for patients treated in emergency departments.

How similar studies have gone: Other research has shown promise in implementing preventive care in emergency settings, suggesting that this approach could be effective.

Where this research is happening

  • Wake Forest University Health Sciences
    Winston-Salem, United States
    Active

Researchers

  • Principal investigator: Ashburn, Nicklaus — Wake Forest University Health Sciences
  • Study coordinator: Ashburn, Nicklaus

Related research

Other NIH-funded projects on the same topics.

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  • PFAS exposure pathways and their link to high cholesterol in rural farmers

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  • Modified FGF1 protein to lower blood fats and protect arteries

    This project develops a modified natural protein (FGF1) to lower blood fats and help people with diabetes or metabolic syndrome avoid artery-clogging plaque.

    NIH research University of Louisville · Louisville, United States · NIH-11235157

  • Fibroblast growth factor 1 helps prevent high cholesterol and artery disease

    This study is looking at a special version of a protein called FGF1 to see if it can help lower cholesterol and prevent plaque buildup in arteries, which could lead to a safer treatment option for people dealing with heart issues, diabetes, or fatty liver disease.

    NIH research University of Louisville · Louisville, United States · NIH-10984962

  • IL-19's role in improving lymphatic function during high cholesterol levels

    This study is looking at how a protein called IL-19 influences the lymphatic system and inflammation related to heart disease, with the hope that improving lymphatic function could help reduce harmful plaque in arteries, which might lead to new treatments for better heart health.

    NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-10825817

  • How diet affects liver cell changes and cholesterol levels

    This study is looking at how what we eat affects liver cells as we get older, especially for people who struggle with lowering their cholesterol even with medications, and it hopes to find ways to help them manage their cholesterol better through diet changes.

    NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-10674261

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.