Using tissue monitoring to improve surgery for brain tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the use of an aspirate tissue monitor (ATM) during neurosurgery for high-grade gliomas. The ATM detects cancerous tissue from suction waste in near real-time, providing audible feedback to surgeons when tumor-related fluorescence is identified. By integrating this technology with 5-aminolevulinic acid (5-ALA) fluorescence-guided surgery, the trial aims to enhance tumor removal efficiency, reduce blood loss, and minimize the risk of leaving residual tumor tissue. The study is multicenter and controlled, involving several prominent hospitals.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient admitted to neurosurgery department for surgical resection of a suspected high-grade glioma
* Patients aged 18 years old or older
* Informed consent obtained

Exclusion Criteria:

* Patient belongs to the following vulnerable groups: children, pregnant, prisoners or intellectually disabled

Where it's running

• Kuopio University Hospital
  Kuopio, Northern Savonia, Finland Recruiting
• Tampere University Hospital
  Tampere, Pirkanmaa, Finland Recruiting
• Oslo University Hospital
  Oslo, Norway Not yet recruiting

Study contacts

• Principal investigator: Antti-Pekka Elomaa, Docent — Kuopio University Hospital
• Study coordinator: Sami Puustinen, PhD
• Email: sami.puustinen@marginum.com
• Phone: +358442190767

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Preoperative Proton Therapy for High-Grade Brain Tumors

  This trial tests whether giving proton therapy before surgery is tolerable for people with high-grade brain gliomas.

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• G207 with 5 Gy Radiation for pediatric high-grade glioma

  This study tests whether injecting G207 into a brain tumor plus a single 5 Gy radiation dose is safe and could help extend survival for children with recurrent or progressive high-grade gliomas.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT07649070

• Dual-target CAR-NK therapy for adults with recurrent or progressive glioblastoma and other high-grade gliomas

  This study will try giving dual-target CAR-NK cells into the surgical cavity to see if they can help adults with recurrent or progressive glioblastoma or other high-grade gliomas.

  Recruiting Phase 1 Beijing Biotech · Shenzhen, Guangdong · NCT07551336

• Pre-radiation chemotherapy for high-grade glioma

  Researchers are testing whether giving temozolomide before radiation can help patients with newly diagnosed high-grade gliomas see better outcomes and clearer MRI results after treatment.

  Recruiting Phase 2 Cooper Norcross Health · Camden, New Jersey · NCT07439172

• AAV dual-payload gene therapy injected directly into high-grade glioma to kill tumor cells and stimulate immune attack.

  This will try TGX-007, a virus-delivered gene therapy given into the tumor together with oral valaciclovir, in adults 18–70 with newly diagnosed or recurrent glioblastoma to see if it safely kills tumor cells and boosts immune response.

  Recruiting at 2 sites Phase 1/2 Trogenix ltd · Columbus, Ohio and 1 other locations · NCT07346144

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.