Investigating the role of immune cells in childhood brain tumors
The role of Myeloid cells in pediatric-high grade gliomas
This study is looking at how certain immune cells in the brain, called macrophages and neutrophils, affect a type of brain cancer in kids, and it hopes to find new ways to help treat these young patients better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11099934 on NIH RePORTER |
What this research studies
This research focuses on understanding how myeloid cells, particularly tumor-associated macrophages and neutrophils, contribute to pediatric high-grade gliomas, a type of brain cancer in children. By analyzing tissue samples from patients and using advanced RNA sequencing techniques, the researchers aim to uncover the unique characteristics of these immune cells in pediatric tumors compared to adult cases. The study seeks to identify potential therapeutic targets that could improve treatment outcomes for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with pediatric high-grade gliomas, particularly those with specific genetic mutations or inflammatory profiles.
Not a fit: Patients with low-grade gliomas or other types of brain tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve survival rates for children with high-grade gliomas.
How similar studies have performed: Previous research has shown promising results in targeting immune cells in adult gliomas, suggesting potential for similar success in pediatric cases.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Hambardzumyan, Dolores — Icahn School of Medicine at Mount Sinai
- Study coordinator: Hambardzumyan, Dolores
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.