Condition

Hepatoblastoma clinical trials and research

• 10Clinical trials
• 5NIH research projects
• 3Countries

Newest Hepatoblastoma clinical trials

All recruiting trials (10)

• Using blood DNA 5hmC markers and the SCCG chemotherapy protocol to predict response and monitor relapse in children with hepatoblastoma

  This trial will test whether a blood-based DNA marker (5hmC) together with the SCCG treatment plan can predict chemotherapy response and detect recurrence in children and adolescents with hepatoblastoma.

  Recruiting at 2 sites Phase 2 Sun Yat-sen University · Guangzhou, Guangdong and 1 other locations · NCT07300449

• Pucotenlimab with lenvatinib and chemotherapy for children with advanced or relapsed hepatoblastoma

  This study will test whether pucotenlimab combined with lenvatinib and irinotecan can help children aged 2–18 whose hepatoblastoma did not respond to prior treatments.

  Recruiting Sun Yat-sen University · Guangdong, Guangzhou · NCT07188311

• GPC3-targeted CAR T cells armored with IL-15 and IL-21 for pediatric non‑CNS solid tumors

  This treatment will try personalized CAR T cells that target GPC3 and are engineered to make IL‑15 and IL‑21 in children and young adults with relapsed or refractory non‑CNS solid tumors that express GPC3.

  Recruiting Phase 1 Seattle Children's Hospital · Seattle, Washington · NCT07148050

• Observational study of rare primary liver cancers in France

  This study looks at rare types of liver cancer in France to see how they behave and how well different treatments work for patients.

  Recruiting at 29 sites Federation Francophone de Cancerologie Digestive · Amiens and 39 other locations · NCT06541652

• IL-15 and IL-21–armored GPC3-CAR T cell therapy for adults with GPC3-positive solid tumors

  This trial tests whether CAR T cells engineered to target GPC3 and fortified with IL-15 and IL-21 can treat adults with GPC3-positive liver and other solid tumors.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT06198296

• B7-H3 CAR T-cell therapy for pediatric solid tumors

  This study is testing a new type of immune therapy using specially modified T cells to see if it can help children with tough-to-treat solid tumors.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT04897321

• ET140203 T Cells for treating pediatric liver cancer

  This study is testing a new type of T-cell treatment for kids with certain types of liver cancer to see if it is safe and helps them feel better.

  Recruiting at 4 sites Phase 1/2 Eureka Therapeutics Inc. · Los Angeles, California and 3 other locations · NCT04634357

• Treatment for children with newly diagnosed hepatoblastoma using a modified strategy

  This study is testing if a new treatment can help protect children with newly diagnosed liver cancer from hearing loss caused by chemotherapy while also looking at how well different therapies work for their specific cases.

  Recruiting Phase 3 Shanghai Children's Medical Center · Shanghai, Shanghai Municipality · NCT04478292

• Combining vorinostat with chemotherapy for relapsed solid tumors and CNS cancers

  This study is testing if adding a drug called vorinostat to chemotherapy can help people with relapsed solid tumors and brain cancers feel better and improve their treatment outcomes.

  Recruiting Phase 1 New York Medical College · Valhalla, New York · NCT04308330

• Understanding the genetic causes of childhood liver cancer

  This study is trying to find out the genetic causes of childhood liver cancer to help doctors diagnose and treat these rare cancers better.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT03959800

NIH-funded research (5)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• High-risk hepatoblastoma spread control through NRF2 targeting

  This project studies how aggressive liver cancer in children spreads and how turning off NRF2 might prevent it, with the goal of helping kids with high-risk hepatoblastoma survive longer.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11355601

• Controlling the spread of high-risk hepatoblastoma using NRF2

  This work looks at how a protein called NRF2 helps high-risk hepatoblastoma spread in children, hoping to find new ways to stop it.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11140329

• Targeting specific immune cells to improve treatment for childhood liver cancer.

  This study is looking at how certain immune cells might make it harder to treat hepatoblastoma, a type of liver cancer in kids, and aims to find out if getting rid of these cells can help make treatments work better.

  NIH research University of Hawaii at Manoa · Honolulu, United States · NIH-11115204

• Controlling the spread of high-risk liver tumors in children

  This study is looking at how certain cancer cells in the blood of children with hepatoblastoma, especially those with tougher cases, can make treatment less effective, and it hopes to find new ways to help these kids get better.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10886227

• Understanding liver cancer in children using stem cells

  This study is looking at how a type of liver cancer called hepatoblastoma affects kids, and it's using special cells to learn more about the disease and find better treatments that could help young patients.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-10687102

Related topics

Quick answers

How many Hepatoblastoma clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (6 trials), China (3 trials), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 4, Phase 2: 1, Phase 3: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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