Understanding liver cancer in children using stem cells
Modeling Hepatoblastoma using pluripotent stem cell derived hepatocyte-like cells
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-10687102
This study is looking at how a type of liver cancer called hepatoblastoma affects kids, and it's using special cells to learn more about the disease and find better treatments that could help young patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10687102 on ClinicalTrials.gov |
What this research studies
This research focuses on hepatoblastoma, the most common liver cancer in children, which has a low survival rate. By using pluripotent stem cell-derived hepatocyte-like cells, the researchers aim to model this cancer to better understand its mechanisms and develop targeted therapies. The study will investigate the genetic mutations associated with hepatoblastoma and how they affect cell behavior, which could lead to more effective treatments. Patients may benefit from improved clinical therapies that arise from this research.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with hepatoblastoma or those at risk for developing this type of liver cancer.
Not a fit: Patients with other types of cancers or those who are not children may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted treatments for children with hepatoblastoma.
How similar studies have performed: Other research has shown promise in using stem cell models to study various cancers, indicating that this approach could be beneficial for understanding hepatoblastoma as well.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHWARTZ, ROBERT E — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: SCHWARTZ, ROBERT E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer