Observational study of rare primary liver cancers in France
Official title: A French Multicenter Observational Retrospective Study of Rare Primary Liver Cancers
Run by Federation Francophone de Cancerologie Digestive · NCT06541652 · Data updated 2026-11-12
This study looks at rare types of liver cancer in France to see how they behave and how well different treatments work for patients.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Federation Francophone de Cancerologie Digestive Academic / other |
| Locations | 40 sites (Amiens and 39 other locations) |
| Status | Recruiting |
| Started | March 26, 2024 |
| Main results expected | February 2026 |
| Study ends | February 2031 |
| Registry record updated | August 5, 2025 |
| Trial ID | NCT06541652 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older with histologically confirmed rare primary liver cancers diagnosed after January 1, 2018.
✕Probably not a fit
Patients without access to a tumor block or lacking social security may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter observational study aims to describe the clinical, histological, and radiological features of rare primary liver cancers, including hepatocholangiocarcinoma and fibrolamellar carcinoma. It will collect biological tumor samples and blood to evaluate the efficacy of treatments received in clinical practice, helping to determine optimal therapeutic sequences. The findings will serve as a foundation for future translational studies aimed at identifying new biomarkers for diagnosis and treatment evaluation.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and treatment strategies for patients with rare primary liver cancers.
How similar studies have gone: While this study focuses on rare cancers, similar observational studies have shown success in identifying treatment patterns and biomarkers in other cancer types.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years of age or older, * with histologically proven hepato-cholangiocarcinoma, fibrolamellar hepatocellular carcinoma, epithelioid hemangioendothelioma or hepatic angiosarcoma * diagnosed after January 01, 2018 living or deceased at the time of registration in the cohort * for living patients who have not objected to the research: (note of non-objection to be attached° agreeing to participate in ancillary studies must sign the biological consent form for participation in biological studies. Exclusion Criteria: * without social security * No access to tumor block
Where it's running
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CHU Amiens picardie
Amiens, France Recruiting -
Chu Angers
Angers, France Recruiting -
Ch - Centresimone Veil de Beauvais
Beauvais, France Recruiting -
Avicenne
Bobigny, France Recruiting -
Centre Hospitalier
Calais, France Recruiting -
Chu de Clichy Hopital Beaujon
Clichy, France Recruiting
Show 34 more locations
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Centre Hospitalier Universitaire Henri Mondor
Créteil, France Recruiting -
Chu
Dijon, France Recruiting -
Chu Grenobles Alpes
La Tronche, France Recruiting -
Centre Hospital Universitaire de lille
Lille, France Recruiting -
Longjumeau Ch Nord Essone
Longjumeau, France Recruiting -
Ch Edouard Herriot
Lyon, France Recruiting -
Centre Léon Berard
Lyon, France Recruiting -
La Clinique de La Sauvegarde
Lyon, France Recruiting -
Chu Edouard Herriot
Lyon, France Recruiting -
Lyon Cac Leon Berard
Lyon, France Recruiting -
Hopital Saint Joseph
Marseille, France Recruiting -
Chu de La Timone
Marseille, France Recruiting -
CHR - Metz Thionville Hopital de Mercy
Metz, France Recruiting -
Chu de Paris Saint Antoine
Paris, France Recruiting -
AP - HP - Pitié Salpêtrière
Paris, France Recruiting -
Centre Hospitalier de Perpignan
Perpignan, France Recruiting -
Hopital Haut Leveque
Pessac, France Recruiting -
Chu de Poitiers
Poitiers, France Recruiting -
CH - Annecy Genevois
Pringy, France Recruiting -
Chu Robert Debre
Reims, France Recruiting -
Hopital Nord Chu Saint Etienne
Saint-Priest-en-Jarez, France Recruiting -
Groupe Hospitalier Rance Emeraude
St-Malo, France Recruiting -
Chu Rangueil
Toulouse, France Recruiting -
Chu Jean Minjoz
Besançon, France Not yet recruiting -
Ch Bethune Beuvry
Béthune, France Not yet recruiting -
Cote de Nacre
Caen, France Not yet recruiting -
Lyon La Croix Rousse
Lyon, France Not yet recruiting -
CHU La Source
Orléans, France Not yet recruiting -
Pau Ch
Pau, France Not yet recruiting -
CAC - Eugène Marquis
Rennes, France Not yet recruiting -
Ico Site Rene Gauducheau
Saint-Herblain, France Not yet recruiting -
Chru de Tours
Tours, France Not yet recruiting -
Chu Paul Brousse
Villejuif, France Not yet recruiting -
Gustave Roussy
Villejuif, France Not yet recruiting
Study contacts
- Principal investigator: jean-charles nault, Pr — Federation Francophone de Cancerologie Digestive
- Study coordinator: lila gaba
- Email: lila.gaba@u-bourgogne.fr
- Phone: 06 99 78 84 73
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.