Clinical trial Recruiting at 29 sites Observational Ages 18 and up

Observational study of rare primary liver cancers in France

Official title: A French Multicenter Observational Retrospective Study of Rare Primary Liver Cancers

Run by Federation Francophone de Cancerologie Digestive · NCT06541652 · Data updated 2026-11-12

This study looks at rare types of liver cancer in France to see how they behave and how well different treatments work for patients.

More Cholangiocarcinoma trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment150 (estimated)
SponsorFederation Francophone de Cancerologie Digestive
Academic / other
Locations40 sites (Amiens and 39 other locations)
StatusRecruiting
StartedMarch 26, 2024
Main results expectedFebruary 2026
Study endsFebruary 2031
Registry record updatedAugust 5, 2025
Trial IDNCT06541652 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include adults aged 18 and older with histologically confirmed rare primary liver cancers diagnosed after January 1, 2018.

Probably not a fit

Patients without access to a tumor block or lacking social security may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter observational study aims to describe the clinical, histological, and radiological features of rare primary liver cancers, including hepatocholangiocarcinoma and fibrolamellar carcinoma. It will collect biological tumor samples and blood to evaluate the efficacy of treatments received in clinical practice, helping to determine optimal therapeutic sequences. The findings will serve as a foundation for future translational studies aimed at identifying new biomarkers for diagnosis and treatment evaluation.

Why it matters

Potential benefit: If successful, this study could lead to improved understanding and treatment strategies for patients with rare primary liver cancers.

How similar studies have gone: While this study focuses on rare cancers, similar observational studies have shown success in identifying treatment patterns and biomarkers in other cancer types.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 18 years of age or older,
* with histologically proven hepato-cholangiocarcinoma, fibrolamellar hepatocellular carcinoma, epithelioid hemangioendothelioma or hepatic angiosarcoma
* diagnosed after January 01, 2018 living or deceased at the time of registration in the cohort
* for living patients who have not objected to the research: (note of non-objection to be attached° agreeing to participate in ancillary studies must sign the biological consent form for participation in biological studies.

Exclusion Criteria:

* without social security
* No access to tumor block

Where it's running

  • CHU Amiens picardie
    Amiens, France
    Recruiting
  • Chu Angers
    Angers, France
    Recruiting
  • Ch - Centresimone Veil de Beauvais
    Beauvais, France
    Recruiting
  • Avicenne
    Bobigny, France
    Recruiting
  • Centre Hospitalier
    Calais, France
    Recruiting
  • Chu de Clichy Hopital Beaujon
    Clichy, France
    Recruiting
Show 34 more locations
  • Centre Hospitalier Universitaire Henri Mondor
    Créteil, France
    Recruiting
  • Chu
    Dijon, France
    Recruiting
  • Chu Grenobles Alpes
    La Tronche, France
    Recruiting
  • Centre Hospital Universitaire de lille
    Lille, France
    Recruiting
  • Longjumeau Ch Nord Essone
    Longjumeau, France
    Recruiting
  • Ch Edouard Herriot
    Lyon, France
    Recruiting
  • Centre Léon Berard
    Lyon, France
    Recruiting
  • La Clinique de La Sauvegarde
    Lyon, France
    Recruiting
  • Chu Edouard Herriot
    Lyon, France
    Recruiting
  • Lyon Cac Leon Berard
    Lyon, France
    Recruiting
  • Hopital Saint Joseph
    Marseille, France
    Recruiting
  • Chu de La Timone
    Marseille, France
    Recruiting
  • CHR - Metz Thionville Hopital de Mercy
    Metz, France
    Recruiting
  • Chu de Paris Saint Antoine
    Paris, France
    Recruiting
  • AP - HP - Pitié Salpêtrière
    Paris, France
    Recruiting
  • Centre Hospitalier de Perpignan
    Perpignan, France
    Recruiting
  • Hopital Haut Leveque
    Pessac, France
    Recruiting
  • Chu de Poitiers
    Poitiers, France
    Recruiting
  • CH - Annecy Genevois
    Pringy, France
    Recruiting
  • Chu Robert Debre
    Reims, France
    Recruiting
  • Hopital Nord Chu Saint Etienne
    Saint-Priest-en-Jarez, France
    Recruiting
  • Groupe Hospitalier Rance Emeraude
    St-Malo, France
    Recruiting
  • Chu Rangueil
    Toulouse, France
    Recruiting
  • Chu Jean Minjoz
    Besançon, France
    Not yet recruiting
  • Ch Bethune Beuvry
    Béthune, France
    Not yet recruiting
  • Cote de Nacre
    Caen, France
    Not yet recruiting
  • Lyon La Croix Rousse
    Lyon, France
    Not yet recruiting
  • CHU La Source
    Orléans, France
    Not yet recruiting
  • Pau Ch
    Pau, France
    Not yet recruiting
  • CAC - Eugène Marquis
    Rennes, France
    Not yet recruiting
  • Ico Site Rene Gauducheau
    Saint-Herblain, France
    Not yet recruiting
  • Chru de Tours
    Tours, France
    Not yet recruiting
  • Chu Paul Brousse
    Villejuif, France
    Not yet recruiting
  • Gustave Roussy
    Villejuif, France
    Not yet recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • SumMET: Targeted radioligand therapy for c-MET–positive solid tumors

    This first‑in‑human study tests the safety and potential effectiveness of a radioligand therapy called [225Ac]Ac-FL-261 in adults with advanced or metastatic solid tumors that overexpress c-MET.

    Recruiting at 2 sites Phase 1/2 Full-Life Technologies UK Limited · Minneapolis, Minnesota and 1 other locations · NCT07873450

  • 68Ga-SorB PET/CT imaging for solid tumors

    This study tests a new PET tracer called 68Ga-SorB to see if it can safely and accurately detect tumors in adults with melanoma, liver, lung, breast, pancreatic, ovarian cancer, or cholangiocarcinoma.

    Recruiting Peking University Third Hospital · Beijing, Beijing Municipality · NCT07760012

  • Breath test to help detect gastrointestinal cancers early

    A breath test that looks for signals in exhaled air to see if someone with gut cancer symptoms might have oesophageal, stomach, pancreatic, liver, or colorectal cancer and need urgent testing.

    Recruiting Imperial College London · Maidstone, Kent and 5 other locations · NCT07714538

  • Can an imaging tracer help predict if cholangiocarcinoma patients will respond to standard therapy

    This study tests whether an imaging tracer called [18F]FTT used with PET/CT can predict how newly diagnosed cholangiocarcinoma patients will respond to the standard treatment of gemcitabine, cisplatin, and durvalumab.

    Recruiting Phase 2 University of Washington · Seattle, Washington · NCT07673341

  • Dual-target HER2/CEA CAR-NK Cells in Advanced Biliary Tract Cancer

    This trial tests a ready-to-use CAR-NK cell therapy that targets HER2 and CEACAM5 in adults with unresectable or metastatic biliary tract cancers after standard therapy to see if it can help control the disease.

    Recruiting Phase 1/2 Beijing Biotech · Shenzhen, Guangdong · NCT07641036

  • KRAS G12V cancer patients get TCR1188-ABC cell therapy

    This early-phase trial tests whether TCR1188-ABC cells can safely be given to adults with KRAS G12V-mutated metastatic cancers to see if it can help some types of pancreatic, biliary, colorectal, or lung cancer.

    Recruiting Phase 1 University of Pennsylvania · Philadelphia, Pennsylvania · NCT07594067

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.