Controlling the spread of high-risk hepatoblastoma using NRF2
High-risk hepatoblastoma dissemination control by oncogenic NRF2
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11140329
This work looks at how a protein called NRF2 helps high-risk hepatoblastoma spread in children, hoping to find new ways to stop it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11140329 on ClinicalTrials.gov |
What this research studies
Hepatoblastoma is a liver cancer in children, and for those with high-risk forms that have spread or returned, current treatments often don't work well. We believe that certain cancer cells, called circulating tumor cells, are responsible for the cancer spreading and resisting therapy. Our goal is to understand exactly how these cells cause the cancer to spread, especially focusing on the role of a protein called NRF2. By understanding these processes, we hope to develop new, more precise treatments that can specifically target and stop the cancer from spreading.
Who could benefit from this research
Good fit: This research is focused on understanding high-risk hepatoblastoma, particularly in children whose cancer has spread or returned after treatment.
Not a fit: Patients with low-risk hepatoblastoma or other types of cancer may not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could lead to new, more effective treatments for children with high-risk hepatoblastoma, improving their chances of survival.
How similar studies have performed: Preliminary data supports the role of NRF2 in hepatoblastoma spread, indicating a promising, yet still early-stage, approach.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WOODFIELD, SARAH ELIZABETH — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: WOODFIELD, SARAH ELIZABETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.