NIH-funded research Sbir 2 grant

Pediatric Heart Pump to Let Kids Go Home While Waiting for Transplant

Official title: Development of a Novel Pediatric LVAD for Home Discharge of Children Awaiting Heart Transplant

Funded at Corvion, INC. · NIH-11407580 · Data updated 2026-11-12

A new ultra-low-power pediatric heart pump is being developed so children awaiting a heart transplant can go home or live with the device.

More Transplant research and trials

Quick facts

Grant typeSbir 2 grant
Study typeNIH-funded research
Funding institutionCorvion, INC.
NIH-funded
Lab location1 site (Webster, United States)
Project startAugust 10, 2026
Project endJuly 31, 2029
Funding year2026
Award (this year)$1,499,984
NIH project number1R44HL184709-01A1
Project IDNIH-11407580 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates are children with end-stage heart failure who are either awaiting a heart transplant or may require long-term mechanical support.

Less likely to help

Children without end-stage heart failure or those not eligible for LVAD implantation would not benefit.

What this research studies

This project aims to create a pediatric left ventricular assist device (P-LVAD) that is small, implantable, and energy-efficient to allow children with end-stage heart failure to leave the hospital and live at home while awaiting a transplant or for long-term use. The device focuses on hemocompatibility and low power use to reduce the burden of bulky pumps and heavy batteries for kids. Researchers will advance the blood pump technology and integration with pediatric patients, aiming to improve quality of life and mobility during this challenging period. The work is conducted by Corventix? Corvion, Inc. under Greg Aber, and involves translating engineering advances into a clinically viable pediatric MCS option.

Why it matters

Potential benefit: If successful, this P-LVAD could dramatically improve quality of life for children awaiting heart transplant by enabling home care and greater daily activity.

How similar studies have gone: Current Berlin Heart devices require hospitalization; this project explores a smaller, energy-efficient alternative that could enable home use.

Where this research is happening

  • Corvion, INC.
    Webster, United States
    Active

Researchers

  • Principal investigator: Aber, Greg — Corvion, INC.
  • Study coordinator: Aber, Greg

Related research

Other NIH-funded projects on the same topics.

  • Predicting acute rejection in children after heart transplant

    A study to improve how doctors predict if a child who has had a heart transplant will have acute rejection using noninvasive blood markers and advanced heart MRI analysis.

    NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11364137

  • Molecular mismatch as a marker of immune risk in heart transplant patients

    A study to see if specific biological differences between donor and recipient hearts can predict immune reactions and guide personalized immunosuppression in people who receive heart transplants.

    NIH research New York University School of Medicine · New York, United States · NIH-11361056

  • Fair and efficient heart transplant allocation using AI-powered continuous distribution

    A NIH-funded project will develop fair and efficient computer-based methods to match donated hearts with patients needing transplants.

    NIH research University of Chicago · Chicago, United States · NIH-11298724

  • Better ways to find heart transplant rejection in children

    This research aims to find less invasive and more accurate ways to detect when a child's body is rejecting a new heart.

    NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11109734

  • Investigating a medication to protect kidney function in heart transplant patients

    This study is looking at whether a medication called empagliflozin can help improve kidney health and overall well-being in heart transplant patients who are at risk for kidney and heart problems, and we're inviting Veterans to join us in this important research.

    NIH research VA Salt Lake City Healthcare System · Salt Lake City, United States · NIH-11048998

  • Discovering biomarkers to improve heart transplant outcomes

    This study is looking at how new technologies can help find important signs in heart transplant patients to better predict and manage issues like rejection, so that doctors can provide more personalized care and improve recovery for those patients.

    NIH research New York University School of Medicine · New York, United States · NIH-10997887

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.