Improving detection of acute rejection in children who have heart transplants
Predictive modeling of acute rejection in pediatric heart transplant recipients
This study is looking for safer ways to check for heart transplant rejection in kids by using blood tests and special imaging instead of needing risky biopsies, helping to keep young patients healthier and more comfortable.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10875416 on NIH RePORTER |
What this research studies
This research focuses on developing non-invasive methods to detect acute rejection in pediatric heart transplant recipients, which is a major cause of mortality in this population. The study aims to utilize blood biomarkers and advanced cardiac imaging techniques to reduce the need for invasive biopsies, which carry risks, especially for children. By analyzing blood samples for specific markers and employing advanced imaging methods, the research seeks to create a predictive model that can accurately identify rejection episodes without the complications associated with traditional biopsy procedures.
Who could benefit from this research
Good fit: Ideal candidates for this research are children who have undergone heart transplantation and are at risk for acute rejection.
Not a fit: Patients who have not received a heart transplant or those who are not at risk for acute rejection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective monitoring of heart transplant patients, potentially reducing the need for invasive procedures.
How similar studies have performed: Other research has shown promise in using non-invasive methods for detecting acute rejection in transplant patients, indicating that this approach has potential for success.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Soslow, Jonathan Harvey — Vanderbilt University Medical Center
- Study coordinator: Soslow, Jonathan Harvey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.