Effects of resistance training for patients waiting for heart transplants
Official title: Effect of Resistance Training on Functional Capacity, Quality of Life and Cardiac Biomarkers in Patients on the Waiting List for Heart Transplant: a Randomized and Controlled Clinical Trial
Run by University of Sao Paulo General Hospital · NCT06426173 · Data updated 2026-11-12
This study tests if a resistance training program can help heart failure patients waiting for a transplant feel better and improve their overall health.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | University of Sao Paulo General Hospital Academic / other |
| Locations | 1 site (São Paulo, São Paulo) |
| Status | Recruiting |
| Started | June 18, 2024 |
| Main results expected | March 18, 2025 |
| Study ends | June 30, 2027 |
| Registry record updated | June 22, 2026 |
| Trial ID | NCT06426173 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients who have been on the heart transplant list for one month or less and are hemodynamically stable.
✕Probably not a fit
Patients with arrhythmogenic or restrictive heart failure, uncontrolled arrhythmias, or cognitive and orthopedic issues may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial evaluates the impact of a resistance training program on hospitalized patients with heart failure who are on the waiting list for heart transplantation. The study aims to assess improvements in functional capacity, quality of life, and cardiac biomarkers over a 12-week period. Participants will be randomly assigned to either a resistance training group or a control group, with assessments conducted at baseline, 6 weeks, and 12 weeks. Additionally, the study will explore the relationship between frailty and responses to resistance training.
Why it matters
Potential benefit: If successful, this study could enhance the functional capacity and quality of life for patients awaiting heart transplants.
How similar studies have gone: While resistance training has shown promise in other populations, this specific approach for heart failure patients awaiting transplantation is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients included in heart transplant list ≤1 month * hemodynamically stable in the last 48 hours defined as mean arterial pressure (MAP) ≥ 60 mmHg and ≤ 120 mmHg and - Heart rate (HR) ≥ 60 bpm and ≤ 120 mmHg. * dobutamine dose ≤ 10 mcg/kg/min Exclusion Criteria: * heart failure of arrhythmogenic and/or restrictive etiology * presence of uncontrolled acute arrhythmias * cognitive, orthopedic, or neuromotor changes that prevent functional tests from being carried out
Where it's running
-
Instituto do Coração - Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
São Paulo, São Paulo, Brazil Recruiting
Study contacts
- Principal investigator: Juliana A Nascimento, PT, PhD — University of Sao Paulo
- Study coordinator: Juliana A Nascimento, PT, PhD
- Email: juliana.nascimento@fm.usp.br
- Phone: +55 11 30618529
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.