Molecular mismatch as a marker of immune risk in heart transplant patients
Official title: Molecular mismatch as a marker for immunologic risk in heart transplant recipients
Funded at New York University School of Medicine · NIH-11361056 · Data updated 2026-11-12
A study to see if specific biological differences between donor and recipient hearts can predict immune reactions and guide personalized immunosuppression in people who receive heart transplants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 25, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $826,079 |
| NIH project number | 5R01HL179005-02 |
| Project ID | NIH-11361056 on NIH RePORTER |
Who could benefit from this research
✓Could help
Heart transplant recipients who might benefit from tailored immunosuppression based on donor-recipient immune differences.
✕Less likely to help
Patients who do not require significant immunosuppression adjustments or do not have donor-recipient mismatch data may see limited direct benefit.
What this research studies
If you have a heart transplant, your doctors try to tailor medicines to prevent rejection while avoiding side effects. This project looks at detailed genetic differences called HLA eplet mismatches to predict immune risk and guide dosing of immunosuppressive drugs. Using three patient groups and national data, researchers will connect these mismatches to immune responses and outcomes. The goal is to help doctors personalize therapy so patients stay healthy longer after transplant.
Why it matters
Potential benefit: If successful, this work could lead to personalized immunosuppression plans that reduce rejection and treatment-related side effects for heart transplant patients.
How similar studies have gone: In kidney transplant, high-resolution mismatch analysis has guided risk categories and treatment decisions; this study tests applicability to heart transplant.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Lonze, Bonnie Elizabeth — New York University School of Medicine
- Study coordinator: Lonze, Bonnie Elizabeth
Related research
Other NIH-funded projects on the same topics.
-
Pediatric Heart Pump to Let Kids Go Home While Waiting for Transplant
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-
Predicting acute rejection in children after heart transplant
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-
Better ways to find heart transplant rejection in children
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Investigating a medication to protect kidney function in heart transplant patients
This study is looking at whether a medication called empagliflozin can help improve kidney health and overall well-being in heart transplant patients who are at risk for kidney and heart problems, and we're inviting Veterans to join us in this important research.
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Discovering biomarkers to improve heart transplant outcomes
This study is looking at how new technologies can help find important signs in heart transplant patients to better predict and manage issues like rejection, so that doctors can provide more personalized care and improve recovery for those patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.