Discovering biomarkers to improve heart transplant outcomes
Official title: Multi-omic Biomarker Discovery and Validation in Heart Transplant Patient Populations
Funded at New York University School of Medicine · NIH-10997887 · Data updated 2026-11-12
This study is looking at how new technologies can help find important signs in heart transplant patients to better predict and manage issues like rejection, so that doctors can provide more personalized care and improve recovery for those patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 1, 2020 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $845,245 |
| NIH project number | 7R01AI144522-05 |
| Project ID | NIH-10997887 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have undergone or are scheduled for heart transplantation.
✕Less likely to help
Patients who are not heart transplant recipients or those with contraindications for transplantation may not benefit from this research.
What this research studies
This research investigates how advanced technologies can identify biomarkers in heart transplant patients to better predict and manage complications like acute rejection. By analyzing various biological data, including genomic and proteomic information, the study aims to enhance the precision of diagnoses and treatment strategies for heart transplant recipients. The approach involves integrating multiple types of biological data to create a comprehensive profile of each patient, which could lead to more personalized care and improved survival rates.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and better management of heart transplant patients through personalized treatment strategies.
How similar studies have gone: Other research has shown promise in using multi-omic approaches to improve patient outcomes in various medical fields, suggesting potential success for this novel application in heart transplantation.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Keating, Brendan James — New York University School of Medicine
- Study coordinator: Keating, Brendan James
Related research
Other NIH-funded projects on the same topics.
-
Pediatric Heart Pump to Let Kids Go Home While Waiting for Transplant
A new ultra-low-power pediatric heart pump is being developed so children awaiting a heart transplant can go home or live with the device.
-
Predicting acute rejection in children after heart transplant
A study to improve how doctors predict if a child who has had a heart transplant will have acute rejection using noninvasive blood markers and advanced heart MRI analysis.
-
Molecular mismatch as a marker of immune risk in heart transplant patients
A study to see if specific biological differences between donor and recipient hearts can predict immune reactions and guide personalized immunosuppression in people who receive heart transplants.
-
Fair and efficient heart transplant allocation using AI-powered continuous distribution
A NIH-funded project will develop fair and efficient computer-based methods to match donated hearts with patients needing transplants.
-
Better ways to find heart transplant rejection in children
This research aims to find less invasive and more accurate ways to detect when a child's body is rejecting a new heart.
-
Investigating a medication to protect kidney function in heart transplant patients
This study is looking at whether a medication called empagliflozin can help improve kidney health and overall well-being in heart transplant patients who are at risk for kidney and heart problems, and we're inviting Veterans to join us in this important research.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.