Exploring immune markers linked to mental fatigue in Graves' disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the relationship between immunological markers and mental fatigue in patients diagnosed with Graves' disease. It aims to confirm the association of these markers with persistent mental fatigue after achieving normal thyroid function. A total of 310 patients will be assessed for various psychological and physical symptoms at different stages of their treatment, including before and after achieving euthyroidism. Blood and cerebrospinal fluid samples will be collected to analyze the identified biomarkers alongside thyroid hormones and autoantibodies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Recently diagnosed Graves' disease
* Positive thyroid stimulating hormone (TSH)-receptor antibodies (TRAb)
* Thyroid hormones above the upper reference limit
* Inclusion within three weeks after start of antithyroid drugs

Controls: Matched for gender and age

Exclusion Criteria:

* Person unable to follow protocol as with psychosis, dementia or not able to answer questionnaires in Swedish.
* Recidive of Graves' disease
* Pregnancy

Controls: -Thyroid disease

* Neurological disease

Where it's running

• Endokrina Forskningsenheten, Sahlgrenska University Hospital
  Gothenburg, Sweden Recruiting

Study contacts

• Principal investigator: Helena Filipsson, ass prof — Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Department of Endocrinology, Sahlgrenska University Hospital, Wallenberg Center for Molecular and Translational Medicine, all in Gothenburg, Sweden
• Study coordinator: Karin Tammelin, PhD student
• Email: karin.tammelin@vgregion.se
• Phone: +46313427331

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.