Using corticosteroids before surgery for autoimmune thyroid disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to randomize patients with Graves' disease or Hashimoto's disease who are scheduled for total thyroidectomy. It will evaluate whether a short course of corticosteroids, specifically dexamethasone, can reduce inflammation of the thyroid gland and facilitate a smoother surgical procedure. Participants will be compared against a placebo group to assess the effectiveness of the intervention. The study focuses on patients with positive thyroid autoantibodies undergoing surgery for their condition.

Why it matters

Who can join: the full rules

* Inclusion Criteria:

  ■ Graves' disease or Hashimoto's disease with positive thyroid autoantibodies (TgAb, TPO, TSI, and/or TRAb) undergoing total thyroidectomy for their disease.
* Exclusion Criteria:

  * Pediatric patients \< 18
  * Prior treatment with RAI
  * Prior neck surgeries
  * Known diagnosis of thyroid cancer
  * Diabetic patients on medications
  * A history of adverse reactions to corticosteroids.
  * Patients on any immunosuppressive regimen (such as organ transplant patients or patients treated for other autoimmune conditions). This includes patients with recent history of steroid therapy, or a history of adverse reactions to corticosteroids.

Where it's running

• IU Health North Hospital
  Indianapolis, Indiana, United States Recruiting
• IU Health Methodist Hospital
  Indianapolis, Indiana, United States Recruiting
• IU Health University Hospital
  Indianapolis, Indiana, United States Recruiting

Study contacts

• Principal investigator: Alexandria McDow, MD — Indiana University
• Study coordinator: Alexandria McDow, MD
• Email: amcdow@iu.edu
• Phone: 317-944-4377

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.